Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Sassari, Italy.
Biomedical Science PhD School, Biomedical Science Department, University of Sassari, Sassari, Italy.
J Laryngol Otol. 2021 Aug;135(8):723-728. doi: 10.1017/S0022215121001651. Epub 2021 Jun 29.
To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients.
Patients underwent psychophysical olfactory assessment with the Connecticut Chemosensory Clinical Research Center test, and determination of blood serum levels of the inflammatory markers D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio within 10 days of the clinical onset of coronavirus disease 2019 and 60 days after.
Seventy-seven patients were included in this study. D-dimer, procalcitonin, ferritin and neutrophil-to-lymphocyte ratio correlated significantly with severe coronavirus disease 2019. No significant correlations were found between baseline and 60-day Connecticut Chemosensory Clinical Research Center test scores and the inflammatory markers assessed.
Olfactory disturbances appear to have little prognostic value in predicting the severity of coronavirus disease 2019 compared to D-dimer, ferritin, procalcitonin and neutrophil-to-lymphocyte ratio. The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors.
分析 2019 年冠状病毒病患者嗅觉心理物理学评分与血清 D-二聚体、C 反应蛋白、铁蛋白、乳酸脱氢酶、降钙素原和中性粒细胞与淋巴细胞比值之间的相关性。
患者在发病后 10 天内和 60 天内接受了康涅狄格州化学感觉临床研究中心测试的心理物理学嗅觉评估，并测定了血清中炎症标志物 D-二聚体、C 反应蛋白、铁蛋白、乳酸脱氢酶、降钙素原和中性粒细胞与淋巴细胞比值的水平。
本研究共纳入 77 例患者。D-二聚体、降钙素原、铁蛋白和中性粒细胞与淋巴细胞比值与严重 2019 年冠状病毒病显著相关。在基线和 60 天的康涅狄格州化学感觉临床研究中心测试评分与所评估的炎症标志物之间未发现显著相关性。
与 D-二聚体、铁蛋白、降钙素原和中性粒细胞与淋巴细胞比值相比，嗅觉障碍在预测 2019 年冠状病毒病严重程度方面似乎没有什么预后价值。嗅觉障碍的严重程度和持续时间与血清炎症标志物水平之间缺乏相关性，这进一步表明 2019 年冠状病毒病患者嗅觉丧失的发病机制与局部而非全身炎症因素有关。
