School of Public Health, Curtin University, Bentley, WA, Australia.
School of Medicine, University of Queensland, Brisbane, Australia.
Addiction. 2022 Feb;117(2):425-432. doi: 10.1111/add.15629. Epub 2021 Jul 14.
Cannabis use is increasing among women of reproductive age, warranting a greater understanding of the impact of prenatal cannabis use on offspring developmental outcomes. We tested for a potential relationship between prenatal cannabis use disorders (CUD) and offspring educational outcomes across primary and secondary school.
Data were drawn from the New South Wales (NSW) Perinatal Data Collection, which included all live births in the Australian state of NSW between January 2003 and December 2005. These were linked with the NSW Admitted Patient Data collection for mothers and offspring, and the NSW National Assessment Program-Literacy and Numeracy (NAPLAN).
New South Wales, Australia.
A total of 189 558 offspring who completed the NAPLAN in grades 3, 5 and 7 (resulting in 568 674 examination periods).
The exposure variable was ICD-10 cannabis use disorders (CUD = F13.0-F13.9). The study included five outcome variables measured at three time-points as not meeting the minimum national standards for: (i) numeracy, (ii) reading, (iii) spelling, (iv) writing and (v) grammar and punctuation.
In unadjusted analyses, prenatal CUD was associated with an increased risk for not meeting the national minimum standard of all outcomes [odds ratios (OR) ranging from 3.42 (95% confidence interval (CI) = 2.94, 3.99) to 4.17 (95% CI = 3.55, 4.91)], with no evidence for an interaction across time. However, the associations attenuated greatly after exact matching by covariates, with reading and numeracy no longer associated with prenatal CUD, while the increased risk of the other outcomes ranged from OR = 1.31 (95% CI = 1.09, 1.57) to OR = 1.40 (95% CI = 1.17, 1.68).
Socio-economic status appears to confound the association between prenatal cannabis use disorder and poor educational performance in offspring.
在育龄妇女中，大麻的使用呈上升趋势，这就需要更深入地了解产前大麻使用对后代发育结果的影响。我们检测了产前大麻使用障碍（CUD）与整个小学和中学阶段的后代教育结果之间的潜在关系。
数据来自新南威尔士州（NSW）围产期数据收集，该数据包括 2003 年 1 月至 2005 年 12 月期间澳大利亚新南威尔士州的所有活产儿。这些数据与新南威尔士州母亲和后代的入院患者数据收集以及新南威尔士州国家评估计划-读写和算术（NAPLAN）相关联。
新南威尔士州，澳大利亚。
共有 189558 名完成 NAPLAN 考试的子女，包括 3 年级、5 年级和 7 年级（共 568674 次考试）。
暴露变量为 ICD-10 大麻使用障碍（CUD=F13.0-F13.9）。该研究包括五个在三个时间点测量的结果变量，未达到以下最低国家标准：（i）算术、（ii）阅读、（iii）拼写、（iv）写作和（v）语法和标点。
在未调整的分析中，产前 CUD 与所有结果不符合国家最低标准的风险增加有关（比值比（OR）范围为 3.42（95%置信区间（CI）=2.94，3.99）至 4.17（95% CI=3.55，4.91）），且在时间上没有相互作用的证据。然而，在通过协变量进行精确匹配后，相关性大大减弱，阅读和算术与产前 CUD 不再相关，而其他结果的风险增加范围从 OR=1.31（95% CI=1.09，1.57）到 OR=1.40（95% CI=1.17，1.68）。
社会经济地位似乎混淆了产前大麻使用障碍与后代教育成绩不佳之间的关联。
