National Institute of Standards and Technology, Materials Measurement Science Division, Gaithersburg, Maryland 20899, United States.
RTI International, Research Triangle Park, North Carolina 27709, United States.
J Am Soc Mass Spectrom. 2021 Aug 4;32(8):2274-2280. doi: 10.1021/jasms.1c00103. Epub 2021 Jun 29.
A confined direct analysis in a real time mass spectrometry (DART-MS) system and method were developed for coupling directly with commercial electronic cigarettes for rapid analysis without sample preparation. The system consisted of a confining heated glass T-junction, DART ionization source, and Vapur interface to assist aerodynamic transport. Suction generated by positioning the electronic cigarette at the junction inlet allowed for direct chemical analysis of aerosolized electronic liquids from both automatic devices powered by drag and manual button-operated devices, which is unachievable with traditional DART-MS. Parametric analyses for the system investigated Vapur suction flow rate, junction heating, puff duration, and coil power levels. Using this method, rapid chemical analyses of electronic cigarette aerosols from electronic liquids, spiked illicit drugs, and polymeric or plasticizer contaminants were performed in <30 s. The confined DART-MS method provides a streamlined tool for rapid screening of illicit and hazardous chemical profiles emitting from electronic cigarettes.
开发了一种受限直接实时质谱（DART-MS）系统和方法，可直接与商业电子烟耦合，无需样品制备即可快速分析。该系统由一个受限加热的玻璃 T 型接头、DART 离子源和 Vapur 接口组成，以协助气动传输。通过将电子烟定位在接头入口处产生的吸力允许直接分析气溶胶化的电子烟液体，无论是由气流驱动的自动设备还是手动按钮操作的设备，这是传统 DART-MS 无法实现的。该系统的参数分析研究了 Vapur 抽吸流速、接头加热、抽吸持续时间和线圈功率水平。使用这种方法，可在<30 秒内对电子烟液体、掺杂的非法药物以及聚合体或增塑剂污染物的电子烟气溶胶进行快速化学分析。受限 DART-MS 方法为快速筛选电子烟中释放的非法和有害化学物质提供了一种简化的工具。
