Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
FEBS J. 2021 Sep;288(17):5122-5129. doi: 10.1111/febs.16096. Epub 2021 Jul 12.
The SARS-CoV-2 pandemic has significantly impacted global health. Research on viral mechanisms, highly effective vaccines, and other therapies is in progress. Neuropilins have recently been identified as host cell receptors enabling viral fusion. Here, we provide context to neuropilin's tissue-specific role in infection and the potential impact of NRP-based therapeutics. We conclude that the central roles of neuropilins in vascular, neural, and other pathways may render it a less suitable target for treating SARS-CoV-2 than agents that target its binding partner, the viral spike protein.
SARS-CoV-2 大流行对全球健康造成了重大影响。目前正在研究病毒机制、高效疫苗和其他疗法。最近发现神经纤毛蛋白是宿主细胞受体，使病毒融合。在这里，我们提供神经纤毛蛋白在感染中的组织特异性作用的背景，并探讨基于 NRP 的治疗方法的潜在影响。我们的结论是，神经纤毛蛋白在血管、神经和其他途径中的核心作用可能使其成为治疗 SARS-CoV-2 的不太合适的靶点，而针对其结合伙伴——病毒刺突蛋白的药物可能更具优势。
