Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD, USA.
RTI International, Research Triangle Park, NC, USA.
Prev Med. 2021 Sep;150:106707. doi: 10.1016/j.ypmed.2021.106707. Epub 2021 Jun 26.
The main purpose of this analysis is to quantify quality adjusted life years (QALYs) lost associated with lifetime exclusive cigarette or smokeless tobacco use among U.S. adults. Multiple waves of National Health Interview Survey (NHIS) data linked to death certificate records were used to define current exclusive cigarette and smokeless tobacco use and associated mortality risks. NHIS data were used to assess health-related quality of life (HRQOL). Regression and Cox proportional hazard modeling were used to adjust HRQOL and mortality risk associated with tobacco use for age, sex, race/ethnicity, body mass index, education, and household poverty level. QALYs were estimated based on adjusted HRQOL and mortality risks. All analyses were initiated in 2019 and completed in 2020. Male current exclusive cigarette smokers, aged 25 to 29 years would lose 8.1 QALYs (SE = 0.09), and male current exclusive smokeless tobacco users aged 25 to 34 would lose 4.1 QALYs (SE = 0.22), compared to never users of tobacco. Current exclusive cigarette or smokeless tobacco use is associated with QALY loss. QALYs lost can be lessened through preventing the initiation of tobacco product use or helping tobacco product users quit as early in life as possible.
本分析的主要目的是量化美国成年人终生只使用香烟或无烟烟草所导致的质量调整生命年（QALYs）损失。使用了多轮国家健康访谈调查（NHIS）数据与死亡证明记录进行关联，以确定当前只使用香烟和无烟烟草的情况以及相关的死亡风险。NHIS 数据用于评估与健康相关的生活质量（HRQOL）。回归和 Cox 比例风险模型用于调整与烟草使用相关的 HRQOL 和死亡率风险，以考虑年龄、性别、种族/民族、体重指数、教育程度和家庭贫困水平等因素。根据调整后的 HRQOL 和死亡率风险来估计 QALYs。所有分析均于 2019 年开始，并于 2020 年完成。与从不吸烟的人相比，25 至 29 岁的男性当前只使用香烟的吸烟者将损失 8.1 个 QALYs（SE=0.09），而 25 至 34 岁的男性当前只使用无烟烟草的使用者将损失 4.1 个 QALYs（SE=0.22）。目前只使用香烟或无烟烟草会导致 QALY 损失。通过预防开始使用烟草制品或帮助烟草制品使用者尽早戒烟，可以减少损失的 QALYs。
