Department of Rehabilitation, Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Department of Medical Informatics and Statistics, Niigata University Graduate School of Medical and Dental Sciences, Niigata 950-2181, Japan.
Int J Environ Res Public Health. 2021 Sep 22;18(19):9970. doi: 10.3390/ijerph18199970.
Various lifestyle behaviors have been known to affect health-related quality of life (HRQL) and life expectancy. However, the impact on quality-adjusted life years (QALYs), which can be used for health economics, has not been clarified. The purpose of this study was to estimate the impact of lifestyle behaviors on lifetime QALYs. We first examined the relationship between lifestyle behaviors and HRQL as measured by the EQ-5D-5L among 4000 participants via a web-based survey. The results of multiple regression analysis showed that physical activity and sleep were significantly related to HRQL. Therefore, we used microsimulation to estimate QALYs from physical activity and sleep, which were determined to be significant in the regression analysis. The results showed that there was a difference of 3.6 QALYs between the recommended lifestyle scenario (23.4 QALYs; 95%CI 3.6 to 35.1) and the non-recommended lifestyle scenario (19.8 QALYs; 95%CI 3.1 to 31.6). This difference was greater in the younger age group than in the older age group. The results also indicated a large difference in QALYs between physical activity and sleep. These findings may provide a significant suggestion for future health promotion measures.
各种生活方式行为已被证实会影响健康相关生活质量（HRQL）和预期寿命。然而，对于可用于健康经济学的质量调整生命年（QALYs）的影响尚未明确。本研究旨在估计生活方式行为对终身 QALYs 的影响。我们首先通过在线调查对 4000 名参与者的生活方式行为与 EQ-5D-5L 测量的 HRQL 之间的关系进行了检查。多元回归分析的结果表明，身体活动和睡眠与 HRQL 显著相关。因此，我们使用微观模拟来估计从身体活动和睡眠中确定的回归分析中具有显著意义的 QALYs。结果表明，在推荐的生活方式情景（23.4 QALYs；95%CI 3.6 至 35.1）和不推荐的生活方式情景（19.8 QALYs；95%CI 3.1 至 31.6）之间，存在 3.6 个 QALYs 的差异。在年轻组中，这种差异大于老年组。结果还表明，身体活动和睡眠之间的 QALYs 差异很大。这些发现可能为未来的健康促进措施提供重要建议。
