Hospital Israelita Albert Einstein, São Paulo, Brazil.
Post-graduate Program in Rehabilitation Sciences, University Nove de Julho, São Paulo, Brazil.
J Vasc Res. 2021;58(6):388-391. doi: 10.1159/000516499. Epub 2021 Jun 29.
Isometric handgrip training (IHT) promotes vascular adaptations in different populations.
We assessed the sex differences in vascular adaptations of IHT in a sample of older adults with symptomatic peripheral artery disease (PAD).
Fifty-three older patients with symptomatic PAD (6 women and 13 men in IHT and 13 women and 21 men in the control group) participated in this study. The IHT group performed 3 sessions per week, for 8 weeks, consisting of 4 sets of isometric contractions for 2 min at 30% of maximum voluntary contraction and a 4-min interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. Blood flow and brachial flow-mediated dilation were analyzed at before and after 8 weeks of intervention. We compared the responses (Δ = post-pre values) of each group (women control, women IHT, men control, and men IHT) with a Kruskal-Wallis test.
There were no differences in all groups after 8 weeks of IHT in Δ brachial diameter (p = 0.850), Δ flow-mediated dilation (p = 0.241), Δ time to peak diameter (p = 0.528), and Δ FMD/AUC (p = 0.397).
There are no effects of sex on vascular adaptation after 8 weeks of IHT in older adults with symptomatic PAD.
等长握力训练（IHT）可促进不同人群的血管适应性变化。
我们评估了等长握力训练对有症状外周动脉疾病（PAD）的老年患者血管适应性变化的性别差异。
53 名有症状 PAD 的老年患者（IHT 组 6 名女性和 13 名男性，对照组 13 名女性和 21 名男性）参与了这项研究。IHT 组每周进行 3 次训练，共 8 周，包括 4 组 30%最大自主收缩的等长收缩，每组之间间隔 4 分钟。对照组接受压缩球治疗，以最小化安慰剂效应，代表假训练。在干预 8 周前后分析血流和肱动脉血流介导的扩张。我们使用 Kruskal-Wallis 检验比较了每组（女性对照组、女性 IHT 组、男性对照组和男性 IHT 组）的反应（Δ=干预前后值）。
IHT 8 周后，各组的肱动脉直径变化（Δ brachial diameter，p = 0.850）、血流介导的扩张变化（Δ flow-mediated dilation，p = 0.241）、峰值直径时间变化（Δ time to peak diameter，p = 0.528）和 FMD/AUC 变化（Δ FMD/AUC，p = 0.397）均无差异。
在有症状 PAD 的老年患者中，IHT 8 周后，性别对血管适应性变化没有影响。
