Institute of Cardiology of Rio Grande Do Sul/University Foundation of Cardiology, Unidade de Pesquisa, 3ºAndar, Av. Princesa Isabel, 395 Santana, Porto Alegre, RS, 90620-001, Brazil.
BMC Cardiovasc Disord. 2021 Feb 17;21(1):101. doi: 10.1186/s12872-021-01849-2.
Aerobic exercise improves endothelial function and arterial stiffness after myocardial infarction (MI), but the effects of isometric exercise on cardiovascular parameters are still uncertain. We aimed to assess the effects of one session of aerobic or isometric exercise on flow-mediated dilation (FMD) and pulse wave velocity (PWV) in post-MI volunteers undergoing percutaneous coronary intervention (PCI).
Twenty post-MI patients undergoing PCI were randomized to aerobic (AE, n = 10) or isometric (IE, n = 10) exercise groups. We evaluated cardiac structure and function (echocardiographic); carotid plaque presence (ultrasound). FMD and PWV were measured 10 min before and 10 min after the intervention: a single session of moderate-intensity AE (30 min; ratings 12-14 on Borg's scale or 50-60% HRreserve) or handgrip IE (four two-minute bilateral contractions; 30% maximal voluntary contraction; 1-min rest). Generalized estimating equations (Bonferroni post-hoc) was used to assess differences (p ≤ 0.050).
FMD improved only in the AE group (Δ = 4.9%; p = 0.034), with no difference between groups after exercise. Even after adjustment (for baseline brachial artery diameter) the effectiveness of AE remained (p = 0.025) with no change in the IE group. PWV was slightly reduced from baseline in the AE group (Δ = 0.61 m/s; p = 0.044), and no difference when compared to the IE group. Peripheral vascular resistance decreased in AE versus IE (p = 0.050) and from baseline (p = 0.014).
Vascular measurements (FMD and PWV) improved after a single session of AE. There are apparently no benefits following a session of IE.
http://www.clinicaltrials.gov and ID number NCT04000893.
有氧运动可改善心肌梗死后患者的内皮功能和动脉僵硬度，但等长运动对心血管参数的影响尚不确定。我们旨在评估单次有氧运动或等长运动对行经皮冠状动脉介入治疗（PCI）的心肌梗死后志愿者的血流介导的舒张功能（FMD）和脉搏波速度（PWV）的影响。
20 名接受 PCI 的心肌梗死后患者被随机分为有氧运动（AE）组（n=10）和等长运动（IE）组（n=10）。我们评估了心脏结构和功能（超声心动图）；颈动脉斑块的存在（超声）。在干预前 10 分钟和干预后 10 分钟测量 FMD 和 PWV：单次中等强度的 AE（30 分钟；Borg 量表评分为 12-14 或 50-60% HRreserve）或双手握力 IE（四次双侧两分钟收缩；30%最大自主收缩；1 分钟休息）。使用广义估计方程（Bonferroni 事后检验）评估差异（p≤0.050）。
仅在 AE 组中 FMD 得到改善（Δ=4.9%；p=0.034），运动后两组之间无差异。即使在调整（基线肱动脉直径）后，AE 的效果仍然存在（p=0.025），IE 组没有变化。AE 组的 PWV 从基线略有降低（Δ=0.61m/s；p=0.044），与 IE 组相比无差异。与 IE 相比，AE 组的外周血管阻力降低（p=0.050），且与基线相比也降低（p=0.014）。
单次 AE 后血管测量（FMD 和 PWV）得到改善。单次 IE 后似乎没有益处。
http://www.clinicaltrials.gov 和 ID 号 NCT04000893。
