Asada Ryuta, Abe Hiroyasu, Hamada Hidetoshi, Fujimoto Yusuke, Choe Hyonmin, Takahashi Daisuke, Ueda Shusuke, Kuroda Yutaka, Miyagawa Takaki, Yamada Kazuki, Tanaka Takeyuki, Ito Juji, Morita Satoshi, Takagi Michiaki, Tetsunaga Tomonori, Kaneuji Ayumi, Inaba Yutaka, Tanaka Sakae, Matsuda Shuichi, Sugano Nobuhiko, Akiyama Haruhiko
Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan.
Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
J Int Med Res. 2021 Jun;49(6):3000605211023336. doi: 10.1177/03000605211023336.
In this study, we aimed to elucidate the relationship between the duration from diagnosis to femoral head collapse and the collapse rate among patients with pre-collapse osteonecrosis of the femoral head (ONFH).
In this retrospective, observational, multicenter study, we analyzed 268 patients diagnosed with ONFH and classified them using the Japanese Investigation Committee classification. The primary endpoint was duration from the time of diagnosis to femoral head collapse for each type of ONFH.
The 12-, 24-, and 36-month collapse rates among participants were 0%, 0%, and 0% for type A, respectively; 0%, 2.0%, and 10.8% for type B, respectively; 25.5%, 40.8%, and 48.5% for type C-1, respectively; and 57.4%, 70.3%, and 76.7% for type C-2 ONFH, respectively. A comparison of unilateral and bilateral ONFH, using Kaplan-Meier survival curves demonstrated similar collapse rates.
The lowest collapse rate was observed for ONFH type A, followed by types B, C-1, and C-2. Additionally, a direct association was observed between the collapse rate and location of the osteonecrotic lesion on the weight-bearing surface.
在本研究中，我们旨在阐明股骨头塌陷前期坏死（ONFH）患者从诊断到股骨头塌陷的持续时间与塌陷率之间的关系。
在这项回顾性、观察性、多中心研究中，我们分析了268例诊断为ONFH的患者，并使用日本调查委员会分类法对他们进行分类。主要终点是每种类型ONFH从诊断到股骨头塌陷的持续时间。
参与者中，A型在12个月、24个月和36个月时的塌陷率分别为0%、0%和0%；B型分别为0%、2.0%和10.8%；C-1型分别为25.5%、40.8%和48.5%；C-2型ONFH分别为57.4%、70.3%和76.7%。使用Kaplan-Meier生存曲线对单侧和双侧ONFH进行比较，结果显示塌陷率相似。
观察到A型ONFH的塌陷率最低，其次是B型、C-1型和C-2型。此外，还观察到塌陷率与负重面上骨坏死病变的位置之间存在直接关联。
