Zhang Mei, Xian Hong-Chun, Dai Li, Tang Ya-Ling, Liang Xin-Hua
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu, 610041, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu, 610041, China.
Cell Biosci. 2021 Jun 29;11(1):117. doi: 10.1186/s13578-021-00630-4.
The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pathogenesis of PNI switches from 'low-resistance channel' hypothesis to 'mutual attraction' theory between peripheral nerves and tumor cells in perineural niche. Among various molecules in perineural niche, microRNA (miRNA) as an emerging modulator of PNI through generating RNA-induced silencing complex (RISC) to orchestrate oncogene and anti-oncogene has aroused a wide attention. This article systematically reviewed the role of microRNA in PNI, promising to identify new biomarkers and offer cancer therapeutic targets.
神经周围浸润（PNI）是指肿瘤细胞侵犯神经，是各种恶性肿瘤中经常出现的临床特征，与术后复发、转移及生存率降低有关。PNI的发病机制已从“低阻力通道”假说转变为神经周围微环境中周围神经与肿瘤细胞之间的“相互吸引”理论。在神经周围微环境的各种分子中，微小RNA（miRNA）作为PNI的一种新兴调节因子，通过生成RNA诱导沉默复合体（RISC）来协调癌基因和抑癌基因，已引起广泛关注。本文系统综述了微小RNA在PNI中的作用，有望识别新的生物标志物并提供癌症治疗靶点。
