多倍体在组织修复和再生中的作用。
Polyploidy in Tissue Repair and Regeneration.
机构信息
Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.
出版信息
Cold Spring Harb Perspect Biol. 2021 Oct 1;13(10):a040881. doi: 10.1101/cshperspect.a040881.
Abstract
Polyploidy is defined as a cell with three or more whole genome sets and enables cell growth across the kingdoms of life. Studies in model organisms have revealed that polyploid cell growth can be required for optimal tissue repair and regeneration. In mammals, polyploid cell growth contributes to repair of many tissues, including the liver, heart, kidney, bladder, and eye, and similar strategies have been identified in and zebrafish tissues. This review discusses the heterogeneity and versatility of polyploidy in tissue repair and regeneration. Polyploidy has been shown to restore tissue mass and maintain organ size as well as protect against oncogenic insults and genotoxic stress. Polyploid cells can also serve as a reservoir for new diploid cells in regeneration. The numerous mechanisms to generate polyploid cells provide an unlimited resource for tissues to exploit to undergo repair or regeneration.
摘要
多倍体是指具有三个或更多整套基因组的细胞，使细胞能够在生命的各个领域中生长。在模式生物中的研究表明，多倍体细胞的生长对于最佳的组织修复和再生是必需的。在哺乳动物中，多倍体细胞的生长有助于许多组织的修复，包括肝脏、心脏、肾脏、膀胱和眼睛，并且在 和斑马鱼组织中也已经确定了类似的策略。本文讨论了多倍体在组织修复和再生中的异质性和多功能性。多倍体已被证明可以恢复组织质量并维持器官大小，以及抵御致癌刺激和遗传毒性应激。多倍体细胞还可以作为再生中新的二倍体细胞的储备库。产生多倍体细胞的众多机制为组织提供了无限的资源，以利用它们进行修复或再生。
相似文献
1
Polyploidy in Tissue Repair and Regeneration.多倍体在组织修复和再生中的作用。
Cold Spring Harb Perspect Biol. 2021 Oct 1;13(10):a040881. doi: 10.1101/cshperspect.a040881.
2
Polyploidy in tissue homeostasis and regeneration.多倍体在组织稳态和再生中的作用。
Development. 2018 Jul 18;145(14):dev156034. doi: 10.1242/dev.156034.
3
Cellular polyploidy in organ homeostasis and regeneration.细胞多倍体在器官稳态和再生中的作用。
Protein Cell. 2023 Aug 1;14(8):560-578. doi: 10.1093/procel/pwac064.
4
Polyploid cardiomyocytes: implications for heart regeneration.多倍体心肌细胞：对心脏再生的影响。
Development. 2021 Jul 15;148(14). doi: 10.1242/dev.199401. Epub 2021 Jul 26.
5
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.肝细胞数量增加的小鼠在慢性肝损伤后保持再生能力，但肝癌的发生率较低。
Gastroenterology. 2020 May;158(6):1698-1712.e14. doi: 10.1053/j.gastro.2020.01.026. Epub 2020 Jan 20.
6
Polyploidy and liver proliferation.多倍体和肝脏增殖。
Clin Res Hepatol Gastroenterol. 2012 Feb;36(1):29-34. doi: 10.1016/j.clinre.2011.05.011. Epub 2011 Jul 21.
7
Hepatocyte Polyploidy: Driver or Gatekeeper of Chronic Liver Diseases.肝细胞多倍体：慢性肝病的驱动因素还是守门人？
Cancers (Basel). 2021 Oct 14;13(20):5151. doi: 10.3390/cancers13205151.
8
Polyploidization of liver cells.肝细胞的多倍体化。
Adv Exp Med Biol. 2010;676:123-35. doi: 10.1007/978-1-4419-6199-0_8.
9
Solving the Polyploid Mystery in Health and Disease.解决健康与疾病中的多倍体之谜。
Trends Genet. 2019 Jan;35(1):6-14. doi: 10.1016/j.tig.2018.10.005. Epub 2018 Nov 21.
10
Functional consequences of somatic polyploidy in development.体细胞多倍体在发育中的功能后果。
Development. 2024 Mar 1;151(5). doi: 10.1242/dev.202392. Epub 2024 Feb 28.
引用本文的文献
1
The role of multi-omics in biomarker discovery, diagnosis, prognosis, and therapeutic monitoring of tissue repair and regeneration processes.多组学在组织修复和再生过程的生物标志物发现、诊断、预后及治疗监测中的作用。
J Orthop Translat. 2025 Aug 8;54:131-151. doi: 10.1016/j.jot.2025.07.006. eCollection 2025 Sep.
2
Melanization regulates wound healing by limiting polyploid cell growth in the Drosophila epithelium.黑化通过限制果蝇上皮细胞中的多倍体细胞生长来调节伤口愈合。
Genetics. 2025 Sep 3;231(1). doi: 10.1093/genetics/iyaf109.
3
Spatial ploidy inference using quantitative imaging.使用定量成像进行空间倍性推断
bioRxiv. 2025 Mar 17:2025.03.11.642217. doi: 10.1101/2025.03.11.642217.
4
Activation of a Src-JNK pathway in unscheduled endocycling cells of the wing disc induces a chronic wounding response.翅盘非定时内循环细胞中Src-JNK信号通路的激活会引发慢性创伤反应。
bioRxiv. 2025 Mar 13:2025.03.12.642788. doi: 10.1101/2025.03.12.642788.
5
Morphological and metabolic changes in Changshan Huyou (Citrus changshan-huyou) following natural tetraploidization.自然四倍体化后常山胡柚（Citrus changshan-huyou）的形态和代谢变化
BMC Plant Biol. 2025 Mar 8;25(1):301. doi: 10.1186/s12870-025-06293-4.
6
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure.α-连环蛋白对LZTS2的力敏结合和隔离导致胞质分裂失败。
J Cell Biol. 2025 Mar 3;224(3). doi: 10.1083/jcb.202308124. Epub 2025 Jan 9.
7
Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration.二酰甘油激酶α调节肝切除术后的肝脏再生。
Sci Rep. 2025 Jan 2;15(1):555. doi: 10.1038/s41598-024-84403-2.
8
Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton.表观基因组和三维基因组图谱揭示了异源四倍体棉花转录调控结构的发育动态和亚基因组不对称性。
Nat Commun. 2024 Dec 27;15(1):10721. doi: 10.1038/s41467-024-55309-4.
9
Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics.多倍体浅表性尿路上皮膀胱屏障细胞在整个生命周期中均表现出细胞衰老特征，且对衰老细胞溶解剂不敏感。
Aging Cell. 2025 Feb;24(2):e14399. doi: 10.1111/acel.14399. Epub 2024 Dec 7.
10
Integrating the Study of Polyploidy Across Organisms, Tissues, and Disease.整合多倍体在生物体、组织和疾病中的研究。
Annu Rev Genet. 2024 Nov;58(1):297-318. doi: 10.1146/annurev-genet-111523-102124. Epub 2024 Nov 14.
本文引用的文献
1
Proliferative polyploid cells give rise to tumors via ploidy reduction.多倍体增殖细胞通过降低倍性产生肿瘤。
Nat Commun. 2021 Jan 28;12(1):646. doi: 10.1038/s41467-021-20916-y.
2
Wound-induced polyploidization is dependent on Integrin-Yki signaling.创伤诱导的多倍体化依赖于整合素-Yki 信号。
Biol Open. 2021 Jan 25;10(1):bio055996. doi: 10.1242/bio.055996.
3
Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division.细胞周期蛋白依赖性激酶 1（CDK1）缺失和肝细胞分裂导致全身脂质代谢重塑和类似糖尿病的表型。
Elife. 2020 Dec 21;9:e63835. doi: 10.7554/eLife.63835.
4
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers.单核RNA测序揭示了多核骨骼肌纤维中的转录异质性。
Nat Commun. 2020 Dec 11;11(1):6374. doi: 10.1038/s41467-020-20063-w.
5
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.单细胞转录组学揭示了合胞体骨骼肌细胞中的功能区隔化。
Nat Commun. 2020 Dec 11;11(1):6375. doi: 10.1038/s41467-020-20064-9.
6
Loss of hepatocyte cell division leads to liver inflammation and fibrosis.肝细胞分裂丧失可导致肝脏炎症和纤维化。
PLoS Genet. 2020 Nov 4;16(11):e1009084. doi: 10.1371/journal.pgen.1009084. eCollection 2020 Nov.
7
Loss of Endogenously Cycling Adult Cardiomyocytes Worsens Myocardial Function.内源性循环成年心肌细胞的丧失会使心肌功能恶化。
Circ Res. 2021 Jan 22;128(2):155-168. doi: 10.1161/CIRCRESAHA.120.318277. Epub 2020 Nov 4.
8
Cytoplasmic sharing through apical membrane remodeling.通过顶膜重塑实现细胞质共享。
Elife. 2020 Oct 14;9:e58107. doi: 10.7554/eLife.58107.
9
Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers.单细胞 RNA 测序和 FISH 鉴定哺乳动物肌纤维中的协调转录活性。
Nat Commun. 2020 Oct 9;11(1):5102. doi: 10.1038/s41467-020-18789-8.
10
Polyploidy in the adult brain.成年大脑中的多倍体现象。
Elife. 2020 Aug 25;9:e54385. doi: 10.7554/eLife.54385.
Zotero 插件