牙周病与乳腺癌风险：来自护士健康研究的结果。
Periodontal Disease and Breast Cancer Risk: Results from the Nurses' Health Study.
机构信息
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, New York.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
出版信息
Cancer Epidemiol Biomarkers Prev. 2021 Sep;30(9):1757-1760. doi: 10.1158/1055-9965.EPI-21-0257. Epub 2021 Jun 29.
BACKGROUND
While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited.
METHODS
We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer.
RESULTS
During 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes.
CONCLUSIONS
We did not observe any association between periodontal disease and breast cancer risk.
IMPACT
Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.
背景
牙周病与癌症风险增加有关，但关于其与乳腺癌之间关联的研究有限。
方法
我们在一项大型前瞻性队列研究（护士健康研究，1998-2014 年）中，研究了自我报告的牙周骨丧失诊断与乳腺癌发病之间的关系。我们使用 Cox 比例风险模型计算了 HR，调整了牙周病和乳腺癌共有的风险因素。
结果
在 1023647 人年的随访期间，报告了 5110 例乳腺癌病例。我们未观察到牙周病与总体乳腺癌风险之间存在关联（HR，1.02；95%置信区间：0.94-1.10）；这种关联不受吸烟状况或其他乳腺癌风险因素或乳腺癌肿瘤亚型的影响。
结论
我们未观察到牙周病与乳腺癌风险之间存在任何关联。
影响
鉴于文献中的结果不一致，需要进一步进行有标准化临床牙周炎测量的研究。
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