英国生物银行中老年人口腔健康状况与乳腺癌风险的相关性研究。
The association between poor oral health and risk of breast cancer in the UK Biobank.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, MSC 9768, Bethesda, MD, 20892, USA.
出版信息
Cancer Causes Control. 2023 Jun;34(6):491-494. doi: 10.1007/s10552-023-01682-2. Epub 2023 Mar 16.
PURPOSE
Specific oral health conditions may be risk factors for breast cancer. This study aimed to investigate the associations of oral health conditions with breast cancer risk.
METHODS
A total of 234,363 women from the UK Biobank prospective cohort were included in this study. We examined the association of self-reported painful/bleeding gums, loose teeth, mouth ulcers, toothache, and use of dentures with the risk of breast cancer. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the associations were calculated with adjustment for multiple confounders.
RESULTS
No associations of self-reported painful/bleeding gums (HR = 1.04, 95% CI 0.98-1.10), loose teeth (HR = 0.92, 95% CI 0.82-1.02), mouth ulcers (HR = 0.99, 95% CI 0.93-1.06), toothache (HR = 1.03, 95% CI 0.92-1.14), or denture use (HR = 0.96, 95% CI 0.91-1.02) with breast cancer risk were found. No statistical heterogeneity was observed in analyses stratified by baseline smoking and menopausal status.
CONCLUSION
We observed no association between self-reported oral health conditions with the risk of breast cancer. Additional research with clinical examinations or oral health biomarkers in diverse populations is warranted.
目的
特定的口腔健康状况可能是乳腺癌的风险因素。本研究旨在探讨口腔健康状况与乳腺癌风险之间的关系。
方法
本研究共纳入了来自英国生物库前瞻性队列的 234363 名女性。我们研究了自述牙龈疼痛/出血、牙齿松动、口腔溃疡、牙痛和使用义齿与乳腺癌风险之间的关系。调整了多个混杂因素后，计算了这些关联的风险比（HRs）和 95%置信区间（95%CI）。
结果
自述牙龈疼痛/出血（HR=1.04，95%CI 0.98-1.10）、牙齿松动（HR=0.92，95%CI 0.82-1.02）、口腔溃疡（HR=0.99，95%CI 0.93-1.06）、牙痛（HR=1.03，95%CI 0.92-1.14）或使用义齿（HR=0.96，95%CI 0.91-1.02）与乳腺癌风险之间均无关联。在按基线吸烟状况和绝经状态分层的分析中，未观察到统计学异质性。
结论
我们未观察到自述口腔健康状况与乳腺癌风险之间存在关联。需要在不同人群中进行有临床检查或口腔健康生物标志物的进一步研究。
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