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辅酶Q10和维生素C对阿霉素诱导的胃黏膜损伤的保护作用及机制以及肠道菌群的影响

Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora.

作者信息

Zhao Xiaomeng, Feng Xueke, Ye Nan, Wei Panpan, Zhang Zhanwei, Lu Wenyu

机构信息

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China.

Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin 300072, PR China.

出版信息

Korean J Physiol Pharmacol. 2021 Jul 1;25(4):261-272. doi: 10.4196/kjpp.2021.25.4.261.

DOI:10.4196/kjpp.2021.25.4.261
PMID:34187945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8255120/
Abstract

Doxorubicin (Dox) is widely used to the treatment of cancer, however, it could cause damage to gastric mucosa. To investigate the protective effects and related mechanisms of coenzyme Q10 (CoQ10) and vitamin C (VC) on Dox-induced gastric mucosal injury, we presented the survey of the 4 groups of the rats with different conditions. The results showed Dox treatment significantly induced GES-1 apoptosis, but preconditioning in GES-1 cells with VC or CoQ10 significantly inhibited the Dox-induced decrease and other harm effects, including the expression and of IκKβ, IκBα, NF-κB/p65 and tumor necrosis factor (TNF-α) in GES-1 cells. Moreover, high-throughput sequencing results showed Dox treatment increased the number of harmful gut microbes, and CoQ10 and VC treatment inhibited this effect. CoQ10 and VC treatment inhibits Dox-induced gastric mucosal injury by inhibiting the activation of the IkKB/IκBα/NF-κB/p65/TNF-α pathway, promoting anti-inflammatory effects of gastric tissue and regulating the composition of the intestinal flora.

摘要

阿霉素（Dox）被广泛用于癌症治疗，然而，它会对胃黏膜造成损伤。为了研究辅酶Q10（CoQ10）和维生素C（VC）对阿霉素诱导的胃黏膜损伤的保护作用及相关机制，我们对4组不同状态的大鼠进行了研究。结果显示，阿霉素处理显著诱导了GES-1细胞凋亡，但用VC或CoQ10预处理GES-1细胞可显著抑制阿霉素诱导的细胞减少及其他有害影响，包括GES-1细胞中IκKβ、IκBα、NF-κB/p65和肿瘤坏死因子（TNF-α）的表达。此外，高通量测序结果表明，阿霉素处理增加了有害肠道微生物的数量，而CoQ10和VC处理可抑制这种效应。CoQ10和VC处理通过抑制IkKB/IκBα/NF-κB/p65/TNF-α途径的激活、促进胃组织的抗炎作用以及调节肠道菌群组成来抑制阿霉素诱导的胃黏膜损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/b7b9ffc4548c/kjpp-25-4-261-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/4a81817191b0/kjpp-25-4-261-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/174e01b9fe72/kjpp-25-4-261-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/f7af23a599c2/kjpp-25-4-261-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/46b4755db02d/kjpp-25-4-261-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/654f9205a8aa/kjpp-25-4-261-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9eb/8255120/b7b9ffc4548c/kjpp-25-4-261-f10.jpg

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