在 T 细胞急性淋巴细胞白血病中 Notch 调控核苷酸代谢。
NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia.
机构信息
Department of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
出版信息
Commun Biol. 2021 Jun 29;4(1):809. doi: 10.1038/s42003-021-02330-8.
Abstract
In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.
摘要
在最近一期的《Science Advances》杂志上，Srivastava 等人报道了 UBR7 在 NOTCH1 驱动的 T-ALL 中具有新的核苷酸生物合成调节作用。在这里，我们将讨论他们的主要发现及其对利用癌症代谢来理解 T-ALL 的发生和进展的意义。
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