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骨水泥型与非骨水泥型半髋关节置换术治疗老年股骨颈骨折患者短期院内死亡率变化的相关性:多中心数据库倾向评分匹配分析。

Association Between Cemented vs Cementless Hemiarthroplasty and Short-Term Change of In-Hospital Mortality in Elderly Patients with Femoral Neck Fracture: A Propensity-Score Matching Analysis in a Multicenter Database.

机构信息

Department of Orthopaedic and Spine Surgery, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

出版信息

Clin Interv Aging. 2021 Jun 21;16:1151-1159. doi: 10.2147/CIA.S315090. eCollection 2021.

Abstract

OBJECTIVE

Cemented hemiarthroplasty is recommended for the vulnerable hip fracture population because of beneficial long-term outcomes. However, the association between cemented hemiarthroplasty and short-term mortality is controversial. To increase a preparedness of potential complication after cemented hemiarthroplasty, we aimed to evaluate the trajectory of the effect of cemented hemiarthroplasty on short-term in-hospital outcomes.

METHODS

We investigated in-hospital mortality and complications between cemented hemiarthroplasty and cementless hemiarthroplasty using a nationwide multicenter database from 2010 to 2016 with a propensity-score matching analysis. We analyzed in-hospital mortality from 1 to 14 days after surgery. We also investigated in-hospital complications that may associate with mortality.

RESULTS

After matching of 31,322 cases, we found no significant difference in 30-day in-hospital mortality between the cemented and cementless hemiarthroplasty groups (hazard ratio, HR [95% confidence interval, CI], 1.2 [0.89-1.6], p = 0.23). However, the 1- to 10-day postoperative mortality rates were significantly higher in the cemented group and the association becomes weaker as the postoperative period increased (day 1; HR [95% CI]: 3.5 [1.6-7.68]; day 10; HR [95% CI]: 1.59 [1.07-2.37]). The incidence of stroke and intensive care unit (ICU) admission was also significantly higher in the cemented group.

CONCLUSION

Cemented hemiarthroplasty was not significantly associated with an increase in overall in-hospital mortality but was significantly associated with short-term mortality from 1-day to 10-day after surgery. The incidence of stroke and ICU admission was also significantly higher in the cemented group. Surgeons should pay more attention to the risk of mortality and stroke in patients undergoing cemented hemiarthroplasty, especially in the early days of hospitalization.

摘要

目的

由于长期结果有利,建议对脆弱性髋部骨折患者进行骨水泥半髋关节置换术。然而,骨水泥半髋关节置换术与短期死亡率之间的关联存在争议。为了提高骨水泥半髋关节置换术后潜在并发症的准备,我们旨在评估骨水泥半髋关节置换术对短期住院结果的影响轨迹。

方法

我们使用 2010 年至 2016 年的全国多中心数据库,通过倾向评分匹配分析,研究骨水泥半髋关节置换术和非骨水泥半髋关节置换术的住院内死亡率和并发症。我们分析了手术后 1 至 14 天的住院内死亡率。我们还研究了可能与死亡率相关的住院内并发症。

结果

在匹配了 31322 例病例后,我们发现骨水泥组和非骨水泥组在 30 天内的住院内死亡率没有显著差异(危险比,HR[95%置信区间,CI],1.2[0.89-1.6],p=0.23)。然而,骨水泥组在术后 1 至 10 天的死亡率明显更高,随着术后时间的延长,这种关联变得越来越弱(第 1 天;HR[95%CI]:3.5[1.6-7.68];第 10 天;HR[95%CI]:1.59[1.07-2.37])。骨水泥组中风和重症监护病房(ICU)入院的发生率也明显更高。

结论

骨水泥半髋关节置换术与总体住院内死亡率的增加无显著相关性,但与术后 1 至 10 天的短期死亡率显著相关。骨水泥组中风和 ICU 入院的发生率也明显更高。外科医生应更加关注接受骨水泥半髋关节置换术患者的死亡风险和中风风险,尤其是在住院的早期。

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