钼靶X线特征与浸润性乳腺癌中的雌激素受体、孕激素受体及人表皮生长因子受体2
Molybdenum Target X-Ray Features and Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 in Invasive Breast Cancer.
作者信息
Tailaiti Gulijire, Maimaiti Gulanbaier, Aikeremu Youlituzi, Tuerdi Batuer
机构信息
Department of Radiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, Xinjiang, People's Republic of China.
出版信息
Int J Gen Med. 2021 Jun 23;14:2777-2783. doi: 10.2147/IJGM.S314055. eCollection 2021.
OBJECTIVE
The aim of this study was to investigate the correlations between molybdenum target X-ray mammography features and the expressions of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in invasive breast cancer (IBC) and their clinical significance.
METHODS
The correlations between the mammographic features and expressions of ER, PR, and HER2 in 378 cases of IBC confirmed by pathology were analyzed retrospectively.
RESULTS
The differences in the ER, PR, and HER2 positive expression between gland types were statistically significant (P < 0.05). The expression of ER was positively correlated with the presence of nipple depression (P < 0.05). Moreover, ER and PR expressions were positively correlated with the absence of axillary lymph node enlargement (P < 0.05) and negatively correlated with the maximum tumor diameter (P < 0.05).
CONCLUSION
The mammographic features of IBC are correlated with the expression of immunity indices ER, PR, and HER2 and reflect several pathological features.
目的
本研究旨在探讨钼靶X线乳腺摄影特征与浸润性乳腺癌（IBC）中雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）表达之间的相关性及其临床意义。
方法
回顾性分析378例经病理确诊的IBC患者的乳腺摄影特征与ER、PR和HER2表达之间的相关性。
结果
不同腺体类型之间ER、PR和HER2阳性表达差异有统计学意义（P < 0.05）。ER表达与乳头凹陷呈正相关（P < 0.05）。此外，ER和PR表达与腋窝淋巴结未肿大呈正相关（P < 0.05），与最大肿瘤直径呈负相关（P < 0.05）。
结论
IBC的乳腺摄影特征与免疫指标ER、PR和HER2的表达相关，并反映了一些病理特征。
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