Garry R F, Witte M H, Gottlieb A A, Elvin-Lewis M, Gottlieb M S, Witte C L, Alexander S S, Cole W R, Drake W L
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112.
JAMA. 1988 Oct 14;260(14):2085-7.
The acquired immunodeficiency syndrome was first recognized as a clinical entity in the United States in the early 1980s; however, the issue of when human immunodeficiency virus, the causative agent of the acquired immunodeficiency syndrome, was introduced into at-risk populations in the United States is unresolved. Previously, we reported the case study of a 15-year-old black male who was admitted to St Louis City Hospital in 1968 for extensive lymphedema of the genitalia and lower extremities. Chlamydial organisms were widely disseminated and isolated from numerous body fluids and organs. Over a 16-month clinical course his condition progressively deteriorated, and at autopsy there was widespread Kaposi's sarcoma of the aggressive, disseminated type. Recently performed Western blot and antigen capture assays on serum and autopsy tissue specimens frozen since 1969 have disclosed that this sexually active teenager was infected with a virus closely related or identical to human immunodeficiency virus type 1. The clinical and immunologic findings together suggest that an immunosuppressive retrovirus existed in the United States before the late 1970s.
获得性免疫缺陷综合征于20世纪80年代初在美国首次被确认为一种临床实体；然而，人类免疫缺陷病毒（获得性免疫缺陷综合征的病原体）何时被引入美国的高危人群这一问题仍未得到解决。此前，我们报告了一例15岁黑人男性的病例研究，该患者于1968年因生殖器和下肢广泛淋巴水肿入住圣路易斯市医院。衣原体广泛传播，并从多种体液和器官中分离出来。在16个月的临床病程中，他的病情逐渐恶化，尸检时发现有广泛的侵袭性、播散型卡波西肉瘤。最近对自1969年以来冷冻的血清和尸检组织标本进行的蛋白质印迹法和抗原捕获试验表明，这名性活跃的青少年感染了一种与1型人类免疫缺陷病毒密切相关或相同的病毒。临床和免疫学发现共同表明，一种免疫抑制逆转录病毒在20世纪70年代末之前就已存在于美国。
