Dualis Herwati, Zefong Abraham Chin, Joo Lim Kai, Dadar Singh Narinderjeet Kaur, Syed Abdul Rahim Syed Sharizman, Avoi Richard, Jeffree Mohammad Saffree, Hassan Mohd Rohaizat, Ibrahim Mohd Yusof, Omar Azizan
Department of Community and Family Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia.
Department of Community Health, National University of Malaysia Medical Center, 56000, Kuala Lumpur, Malaysia.
Ann Med Surg (Lond). 2021 Jun 11;67:102501. doi: 10.1016/j.amsu.2021.102501. eCollection 2021 Jul.
An emerging infectious zoonosis known as Severe Fever with Thrombocytopenia Syndrome (SFTS) is discovered mainly in Japan, South Korea and China. SFTS virus (SFTSV) which is recently recognised as bunyavirus is borne by ticks such as . It has the capabilities to spread as develop clusters and become a considerable public health threat as this virus could experience rapid evolution via gene mutation. Case fatality rate has been reported up to higher than 30%. The aim of this review is to determine the associated risk factors of SFTS and its outcome.
Literature search was conducted using online databases PubMed, ScienceDirect, and Scopus. A total of 517 records were identified from searches in PubMed, ScienceDirect, and Scopus. From the final exclusions, a total of 26 studies were included for final analysis.
Associated risk factors to getting SFTS infection include occupation, history of bite from a tick, biological susceptibility, and owning of domestic animal. Fatality rates apart from single case reports range from 15.1% to 50% and are contributed by various factors including delay in hospital admission, high viral load, older age group and presence of comorbid and complication.
A seroprevalence study can be conducted amongst the high-risk occupation group such as farmers and agricultural workers, as well as testing cases where viral fever is suspected but available tests for other diseases turns out negative.
一种被称为严重发热伴血小板减少综合征（SFTS）的新发人畜共患传染病主要在日本、韩国和中国被发现。SFTS病毒（SFTSV）最近被确认为布尼亚病毒，由诸如蜱等媒介传播。它有能力以集群形式传播，并成为相当大的公共卫生威胁，因为这种病毒可能通过基因突变快速进化。据报道病死率高达30%以上。本综述的目的是确定SFTS的相关危险因素及其结局。
使用在线数据库PubMed、ScienceDirect和Scopus进行文献检索。在PubMed、ScienceDirect和Scopus的检索中总共识别出517条记录。经过最终筛选，共纳入26项研究进行最终分析。
感染SFTS的相关危险因素包括职业、蜱叮咬史、生物易感性和饲养家畜。除个别病例报告外，病死率在15.1%至50%之间，由多种因素导致，包括住院延迟、病毒载量高、老年人群以及存在合并症和并发症。
可以在农民和农业工人等高风险职业群体中开展血清流行率研究，以及对疑似病毒热但其他疾病现有检测结果为阴性的病例进行检测。
