Sansilapin Chalo, Tangwangvivat Ratanaporn, Hoffmann Curtis S, Chailek Chanatip, Lekcharoen Paisin, Thippamom Nattakarn, Petcharat Sininat, Taweethavonsawat Piyanan, Wacharapluesadee Supaporn, Buathong Rome, Kurosu Takeshi, Yoshikawa Tomoki, Shimojima Masayuki, Iamsirithaworn Sopon, Putcharoen Opass
Department of Disease Control, Ministry of Public Health, Mueang, Nonthaburi, Thailand.
Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Rama IV Road, Bangkok, 10330, Thailand.
One Health Outlook. 2024 Oct 1;6(1):18. doi: 10.1186/s42522-024-00112-w.
Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne disease caused by Dabie bandavirus (SFTSV) is an emerging infectious disease of substantial concern in East Asia. In 2019, Ongkittikul S et al. reported the first case of SFTS in Thailand. Our report describes a One Health investigation of SFTS zoonosis examining the index case and suspected animal reservoirs using real-time RT-PCR and immunoassays. We add to the report on the first confirmed case of SFTSV infection in a human in Thailand by conducting a limited but informative One Health surveillance study. Dogs and cats tested positive for SFTSV antibody using IgG ELISA. We conclude that domestic dogs and cats might serve as potential reservoirs for SFTSV spread due to their closer proximity to the index case than other non-domestic animals. Notably, we did not detect SFTSV in synanthropic cats or dogs-nor did we detect SFTSV in Rhipicephalus sanguineus ticks-using RT-PCR. We propose that One Health investigations coupling genomic and serologic assays in response to new SFTS cases could play a pivotal role in preventing and managing SFTS among humans and animals in East Asia. As such, we are establishing a collaborative response to SFTS in Thailand through human outbreak investigations that align with principles of One Health, through environmental surveys and animal RT-PCR and immunoassays. Our investigation highlights the importance of coupling RT-PCR with seroprevalence assays as principal elements of One Health surveillance for SFTS in order to shed light on potential animal reservoirs and track emerging zoonosis.
严重发热伴血小板减少综合征（SFTS）是一种由大别病毒属（SFTSV）引起的蜱传疾病，是东亚地区备受关注的一种新发传染病。2019年，翁吉蒂库尔·S等人报告了泰国首例SFTS病例。我们的报告描述了一项关于SFTS人畜共患病的“同一健康”调查，使用实时逆转录聚合酶链反应（RT-PCR）和免疫测定法检查索引病例和疑似动物宿主。通过开展一项有限但信息丰富的“同一健康”监测研究，我们补充了泰国首例人类SFTSV感染确诊病例的报告。使用IgG酶联免疫吸附测定法（ELISA）检测，狗和猫的SFTSV抗体呈阳性。我们得出结论，由于家犬和家猫比其他非家养动物与索引病例的接触更密切，它们可能是SFTSV传播的潜在宿主。值得注意的是，我们使用RT-PCR在共生猫或狗中未检测到SFTSV，在血红扇头蜱中也未检测到SFTSV。我们建议，针对新出现的SFTS病例，将基因组和血清学检测相结合的“同一健康”调查可在预防和管理东亚地区人类和动物的SFTS中发挥关键作用。因此，我们正在泰国通过与“同一健康”原则相一致的人类疫情调查、环境调查以及动物RT-PCR和免疫测定，建立对SFTS的协作应对措施。我们的调查强调了将RT-PCR与血清流行率检测相结合作为SFTS“同一健康”监测主要内容的重要性，以便揭示潜在的动物宿主并追踪新出现的人畜共患病。
