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严重发热伴血小板减少综合征布尼亚病毒聚集性病例的流行病学和遗传学调查。

Epidemiological and genetic investigation of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus.

机构信息

Liaoning Province Center for Disease Control and Prevention, Shenyang, Liaoning Province, China.

Department of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China.

出版信息

BMC Infect Dis. 2020 May 14;20(1):346. doi: 10.1186/s12879-020-05072-w.

DOI:10.1186/s12879-020-05072-w
PMID:32410583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7227288/
Abstract

BACKGROUND

To analyze and discuss the transmission route of a cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV).

METHOD

We performed an epidemiological investigation and a genetic analysis of patients with severe fever with thrombocytopenia syndrome (SFTS) caused by SFTSV, their close contacts and the surrounding population.

RESULTS

We found that all patients had contact with the blood of the first patient. The comparison of gene sequences in the three isolated SFTSV strains showed that the strains were closely related. Six close contacts and nine individuals in the surrounding population were positive for SFTSV IgM antibody.

CONCLUSION

We suspect that the cluster outbreak was transmitted via blood and that the natural reservoir host of SFTSV exists in the patients' environment.

摘要

背景

分析并讨论一组严重发热伴血小板减少综合征布尼亚病毒(SFTSV)感染病例的传播途径。

方法

对 SFTSV 引起的严重发热伴血小板减少综合征(SFTS)患者、其密切接触者及周围人群进行流行病学调查和基因分析。

结果

我们发现所有患者均与首例患者的血液有接触。对 3 株分离的 SFTSV 基因序列比较显示,株间亲缘关系密切。6 名密切接触者和 9 名周围人群 SFTSV IgM 抗体阳性。

结论

我们怀疑该聚集性疫情是通过血液传播的,SFTSV 的自然储存宿主存在于患者的环境中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156d/7227288/7fa078258998/12879_2020_5072_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156d/7227288/cf9aa1ed1b3c/12879_2020_5072_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156d/7227288/7fa078258998/12879_2020_5072_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156d/7227288/cf9aa1ed1b3c/12879_2020_5072_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156d/7227288/7fa078258998/12879_2020_5072_Fig2_HTML.jpg

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