Capasso Letizia, Coppola Clara, Vendemmia Maria, Salomè Serena, Esposito Valentina, Colinet Chiara, Porfito Carolina, Raimondi Francesco
Neonatology and NICU, Department of Translational Medical Sciences, University Federico II, Naples, Italy.
IDCases. 2021 Jun 11;25:e01188. doi: 10.1016/j.idcr.2021.e01188. eCollection 2021.
Cytomegalovirus (CMV) is the most common cause of congenital infection, with a wide spectrum of clinical manifestations and different grade of severity. We report the case of a male baby born at term with an early prenatal diagnosis of severe intracranial hemorrhage (ICH), with no other evident risk factors. Urine and blood sample were tested for CMV-DNA, and diagnosis of congenital CMV infection was established. This case describes intracranial hemorrhage as uncommon although possible sign of early fetal CMV infection. Considering that pathogenic factors cannot be defined in 25 % of term neonates with ICH, this case report highlights the importance of CMV screening in pregnant women and in term infants with prenatal ICH of unknown origin.
巨细胞病毒（CMV）是先天性感染最常见的病因，具有广泛的临床表现和不同程度的严重性。我们报告一例足月儿男婴，产前早期诊断为严重颅内出血（ICH），无其他明显危险因素。对尿液和血液样本进行了CMV-DNA检测，确诊为先天性CMV感染。本病例描述了颅内出血是胎儿早期CMV感染罕见但可能出现的体征。鉴于25%的足月ICH新生儿无法明确致病因素，本病例报告强调了对孕妇及病因不明的产前ICH足月儿进行CMV筛查的重要性。
