Thorsen Michael, Nielsen Line Anker, Zhai Heng-Xiao, Zhang Qian, Wulf-Andersen Linda, Skov Lars Kobberøe
Novozymes A/S, Krogshoejvej 36, DK-2880 Bagsvaerd, Denmark.
DSM China Animal Nutrition Research Center, Bazhou, Hebei Province, China.
Heliyon. 2021 Jun 5;7(6):e07237. doi: 10.1016/j.heliyon.2021.e07237. eCollection 2021 Jun.
Enzymes can aid in optimal feed stock utilization when used as feed additives. A range of toxicological studies were performed to evaluate the safety profile of a novel phytase (phytase HM) from produced in . Phytase HM was found to be non-mutagenic and non-clastogenic in tests. Further, the phytase HM preparation did not exhibit irritative potential to the eye and skin when applied in models. A 13-week subchronic toxicity study with oral administration of phytase HM to rats did not show any adverse effects. Efficacy studies showed that the dietary supplementation of this phytase significantly improved growth performance and bone mineralization in broiler chickens and piglets fed P-deficient diets, and increased retention of phosphorus (P) and calcium (Ca), and phytate-P degradation in excreta of broiler chickens in a dose-dependent manner. In conclusion, there are no safety concerns using phytase HM as a feed additive and the phytase is well tolerated by broiler chickens and pigs. Further, phytase HM improves with high efficacy the growth performance in both broiler chickens and pigs.
酶作为饲料添加剂使用时，可有助于优化原料利用。开展了一系列毒理学研究，以评估源自[具体产地]的一种新型植酸酶（植酸酶HM）的安全性。在[具体试验]试验中发现植酸酶HM无致突变性和染色体断裂活性。此外，在[具体模型]模型中应用时，植酸酶HM制剂对眼睛和皮肤无刺激性。对大鼠口服植酸酶HM进行的为期13周的亚慢性毒性研究未显示任何不良反应。功效研究表明，在饲喂低磷日粮的肉鸡和仔猪中，日粮添加这种植酸酶可显著改善生长性能和骨矿化，并以剂量依赖的方式提高肉鸡粪便中磷（P）和钙（Ca）的保留率以及植酸磷的降解率。总之，使用植酸酶HM作为饲料添加剂不存在安全问题，肉鸡和猪对该植酸酶耐受性良好。此外，植酸酶HM能高效改善肉鸡和猪的生长性能。
