不同癌症中长链非编码RNA和环状RNA对RUNX蛋白的调控

Farooqi Ammad Ahmad, Gulnara Kapanova, Mukhanbetzhanovna Auyezova Ardak, Datkhayev Ubaidilla, Kussainov Abay Z, Adylova Aima

Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.

Al-Farabi Kazakh National University, 71 Al-Farabi Avenue, Almaty, 050040, Kazakhstan.

Noncoding RNA Res. 2021 May 30;6(2):100-106. doi: 10.1016/j.ncrna.2021.05.001. eCollection 2021 Jun.

RUNX proteins have been shown to behave as "double-edge sword" in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinct modes of cross-regulation of RUNX proteins and non-coding RNAs have been highlighted by recent research. In this review we have attempted to provide an intricate interplay between non-coding RNAs and RUNX proteins in different cancers. Better conceptual and mechanistic understanding of layered regulation of RUNX proteins by non-coding RNAs will be helpful in effective translation of the laboratory findings to clinically effective therapeutics.

RUNX蛋白在多种癌症中表现为“双刃剑”。非编码RNA的发现对增进我们对不同细胞信号通路转录后调控的理解起到了关键作用。近期研究突出了RUNX蛋白与非编码RNA的几种新机制见解及不同的交叉调控模式。在本综述中，我们试图阐述不同癌症中非编码RNA与RUNX蛋白之间复杂的相互作用。更好地从概念和机制上理解非编码RNA对RUNX蛋白的分层调控，将有助于把实验室研究结果有效转化为临床有效疗法。