胃肠道癌症中Notch信号通路与非编码RNA之间的相互作用
Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers.
作者信息
Pan Yangyang, Mao Yuyan, Jin Rong, Jiang Lei
机构信息
Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
出版信息
Oncol Lett. 2018 Jan;15(1):31-40. doi: 10.3892/ol.2017.7294. Epub 2017 Oct 30.
The Notch signaling pathway is one of the main signaling pathways that mediates direct contact between cells, and is essential for normal development. It regulates various cellular processes, including cell proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. It additionally serves an important function in tumor progression. Non-coding RNAs mainly include small microRNAs, long non-coding RNAs and circular RNAs. At present, a large body of literature supports the biological significance of non-coding RNAs in tumor progression. It is also becoming increasingly evident that cross-talk exists between Notch signaling and non-coding RNAs. The present review summarizes the current knowledge of Notch-mediated gastrointestinal cancer cell processes, and the effect of the crosstalk between the three major types of non-coding RNAs and the Notch signaling pathway on the fate of gastrointestinal cancer cells.
Notch信号通路是介导细胞间直接接触的主要信号通路之一，对正常发育至关重要。它调节各种细胞过程，包括细胞增殖、凋亡、迁移、侵袭、血管生成和转移。此外，它在肿瘤进展中发挥重要作用。非编码RNA主要包括小分子微RNA、长链非编码RNA和环状RNA。目前，大量文献支持非编码RNA在肿瘤进展中的生物学意义。Notch信号与非编码RNA之间存在相互作用也日益明显。本综述总结了目前关于Notch介导的胃肠道癌细胞过程的知识，以及三种主要类型的非编码RNA与Notch信号通路之间的相互作用对胃肠道癌细胞命运的影响。
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