非编码RNA在禽类免疫系统中的表观遗传调控
Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System.
作者信息
Chen Xiaolan, Ali Abdalla Bahareldin, Li Zhenhui, Nie Qinghua
机构信息
Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, China.
出版信息
Life (Basel). 2020 Aug 12;10(8):148. doi: 10.3390/life10080148.
The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc. Among them, long non-coding RNAs, circular RNAs, and microRNAs are regulatory RNAs that have different functional mechanisms and were extensively participated in various biological processes. Numerous research studies have found that circular RNAs, long non-coding RNAs, and microRNAs played their important roles in avian immune system during the infection of parasites, virus, or bacterium. Here, we specifically review and expand this knowledge with current advances of circular RNAs, long non-coding RNAs, and microRNAs in the regulation of different avian diseases and discuss their functional mechanisms in response to avian diseases.
已鉴定出的非编码RNA（ncRNA）包括环状RNA、长链非编码RNA、微小RNA、核糖体RNA、小干扰RNA、小核RNA、piwi相互作用RNA和转运RNA等。其中，长链非编码RNA、环状RNA和微小RNA是具有不同功能机制的调控RNA，广泛参与各种生物学过程。大量研究发现，环状RNA、长链非编码RNA和微小RNA在寄生虫、病毒或细菌感染期间的禽类免疫系统中发挥着重要作用。在此，我们结合环状RNA、长链非编码RNA和微小RNA在不同禽类疾病调控方面的最新进展，对这方面的知识进行专门综述和拓展，并讨论它们在应对禽类疾病中的功能机制。
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