Fereshetian Shaunt, Agranat Joshua S, Siegel Nicole, Ness Steven, Stein Thor D, Subramanian Manju L
Boston University School of Medicine, Department of Ophthalmology, Boston, MA, USA.
Boston Medical Center, Boston, MA, USA.
J Alzheimers Dis Rep. 2021 May 3;5(1):375-387. doi: 10.3233/ADR-210283.
Alzheimer's disease (AD) is one of the most common causes of dementia worldwide. Although no formal curative therapy exists for the treatment of AD, considerable research has been performed to identify biomarkers for early detection of this disease, and thus improved subsequent management. Given that the eye can be examined and imaged non-invasively with relative ease, it has emerged as an exciting area of research for evidence of biomarkers and to aid in the early diagnosis of AD. This review explores the current understanding of both protein and retinal imaging biomarkers in the eye. Herein, primary findings in the literature regarding AD biomarkers associated with the lens, retina, and other ocular structures are reviewed.
阿尔茨海默病（AD）是全球痴呆症最常见的病因之一。尽管目前尚无治疗AD的正式治愈性疗法，但已开展了大量研究以确定该疾病早期检测的生物标志物，从而改善后续治疗。鉴于眼睛可以相对轻松地进行非侵入性检查和成像，它已成为一个令人兴奋的研究领域，用于寻找生物标志物证据并辅助AD的早期诊断。本综述探讨了目前对眼部蛋白质和视网膜成像生物标志物的认识。在此，我们回顾了文献中关于与晶状体、视网膜和其他眼部结构相关的AD生物标志物的主要发现。
