Blokhin National Medical Research Center of Oncology, Moscow, Russia.
LLC GeneTechnology, Moscow, Russia.
Dokl Biochem Biophys. 2021 May;498(1):199-202. doi: 10.1134/S1607672921030091. Epub 2021 Jun 29.
Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME.
两种识别 PRAME 蛋白非重叠表位的单克隆抗体被注射到免疫功能正常的小鼠体内，以研究它们对皮下肿瘤生长的影响。使用表达人 PRAME 蛋白的 B16F10 小鼠黑色素瘤系或仅携带不含有 PRAME 基因的载体作为移植物。两种抗体都显示出抑制表达 PRAME 的肿瘤生长的能力，但对不表达 PRAME 的肿瘤没有作用。
