Department of Orthopedics, The Fifth Affiliated Hospital Lishui Municipal Central Hospital, Wenzhou Medical University, Lishui, Zhejiang, People's Republic of China.
Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, Anhui, People's Republic of China.
J Bone Miner Metab. 2021 Nov;39(6):944-951. doi: 10.1007/s00774-021-01243-0. Epub 2021 Jun 29.
The objectives of the present study were to determine whether simvastatin (SIM) could reverse the harmful effects on titanium rod osseointegration in ovariectomized rats fed high-fat diet (HFD).
Ovariectomized female Sprague-Dawley rats were randomly allocated to three groups and received SIM treatment plus HFD for 12 weeks. We then evaluated the microstructure parameters, histological parameters, biomechanical parameters, bone turnover, and blood lipid level.
After 12 weeks of treatment, SIM can significantly improve bone formation around the titanium rod and osseointegration including higher values of maximum push-out force, bone area ratio (BAR), bone-to-implant contact (BIC), bone mineral density (BMD), bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), mean connective density (Conn.D) when compared with the HFD group. In addition, system administration of SIM showed positive effects on collagen type 1 cross-linked C-telopeptide (CTX-1), procollagen I N-terminal propeptide (PINP), total cholesterol (TC), triglycerides (TGL), low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol. Compared with the HFD group, lower values of CTX-1, P1NP, TC, TGL and LDL were observed in the SIM+HFD group (P < 0.05).
Our findings revealed that HFD may have an adverse effect on osseointegration in osteoporotic conditions, and the harmful effect of HFD on osseointegration could be reversed by SIM.
本研究旨在探讨辛伐他汀（SIM）是否可以逆转高脂饮食（HFD）对去卵巢大鼠钛棒骨整合的有害影响。
将去卵巢雌性 Sprague-Dawley 大鼠随机分为 3 组，并接受 SIM 治疗加 HFD 喂养 12 周。然后评估微观结构参数、组织学参数、生物力学参数、骨转换和血脂水平。
治疗 12 周后，SIM 可显著改善钛棒周围的骨形成和骨整合，包括更高的最大推出力、骨面积比（BAR）、骨-种植体接触（BIC）、骨密度（BMD）、骨体积（BV/TV）、骨小梁数量（Tb.N）、骨小梁厚度（Tb.Th）、平均连接密度（Conn.D）。此外，SIM 的系统给药对胶原 I 型交联 C 端肽（CTX-1）、I 型前胶原 N 端前肽（PINP）、总胆固醇（TC）、甘油三酯（TGL）、低密度脂蛋白（LDL）胆固醇和高密度脂蛋白（HDL）胆固醇也有积极影响。与 HFD 组相比，SIM+HFD 组的 CTX-1、P1NP、TC、TGL 和 LDL 值较低（P<0.05）。
我们的研究结果表明，HFD 可能对骨质疏松条件下的骨整合产生不利影响，而 HFD 对骨整合的有害影响可以通过 SIM 逆转。
