Tao Zhou-Shan, Zhou Wan-Shu, Wu Xing-Jing, Zhang Xin, Wang Lin, Xie Jia-Bing, Xu Zhu-Jun, Ding Guo-Zheng, Yang Min
Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe shan Xi Road, Wuhu 241001, Anhui, China.
Department of Geriatrics, The Second Affiliated Hospital of Wannan Medical College, No. 123, Kangfu Road, Wuhu 241000, Anhui, China.
Z Gerontol Geriatr. 2019 Mar;52(2):139-147. doi: 10.1007/s00391-018-1376-x. Epub 2018 Feb 23.
Recently, the use of the pharmacological agents strontium ranelate (SR), parathyroid hormone (1-34, PTH) and zoledronic acid (ZA) has come to prominence for the treatment of osteoporosis due to their ability to prevent bone loss in osteoporotic patients. Although much emphasis has been placed on using pharmacological agents for the prevention of disease, much less attention has been placed on which one is more effective. There is still no direct comparative study on these three drugs. The aim of the present study was to investigate the effect of SR, PTH, ZA on preventing ovariectomy-induced osteoporosis in rats. After bilateral ovariectomy the rats randomly received vehicle, SR (500 mg/kg body weight/day, orally), PTH (20 μg/kg/day, subcutaneously) or a single injection of ZA (0.1 mg/kg, i.v.) until death at 12 weeks. The distal femurs were harvested for evaluation of bone metabolism. The rats treated with ZA demonstrated the highest levels of new bone formation as assessed by microcomputed tomography (CT), biomechanical strength, histological analysis and bone metabolism. Furthermore, PTH and SR showed a stronger effect on improving trabecular bone mass at 12 weeks. The results from the present study demonstrate that systemic administration of PTH, SR and ZA could prevent bone loss, while a single dose of ZA has a better effect on preventing ovariectomy-induced osteoporosis than either PTH or SR.
最近，药理学药物雷奈酸锶（SR）、甲状旁腺激素（1-34，PTH）和唑来膦酸（ZA）因能够预防骨质疏松症患者的骨质流失，在骨质疏松症治疗中备受瞩目。尽管在使用药理学药物预防疾病方面已给予了很多关注，但对于哪种药物更有效却关注较少。目前尚无这三种药物的直接对比研究。本研究的目的是调查SR、PTH、ZA对预防大鼠卵巢切除诱导的骨质疏松症的作用。双侧卵巢切除术后，大鼠随机接受赋形剂、SR（500mg/kg体重/天，口服）、PTH（20μg/kg/天，皮下注射）或单次注射ZA（0.1mg/kg，静脉注射），直至12周时处死。收集股骨远端用于评估骨代谢。通过微型计算机断层扫描（CT）、生物力学强度、组织学分析和骨代谢评估，接受ZA治疗的大鼠表现出最高水平的新骨形成。此外，PTH和SR在12周时对改善小梁骨量显示出更强的作用。本研究结果表明，全身性给予PTH、SR和ZA可预防骨质流失，而单剂量ZA在预防卵巢切除诱导的骨质疏松症方面比PTH或SR效果更好。
