Suppr超能文献

模拟 254nm 紫外线对 N95 口罩不同层消毒的效率。

Modeling the efficiency of UV at 254 nm for disinfecting the different layers within N95 respirators.

机构信息

Department of Civil & Mineral Engineering, University of Toronto, Toronto, Ontario, Canada.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

出版信息

J Biophotonics. 2021 Oct;14(10):e202100135. doi: 10.1002/jbio.202100135. Epub 2021 Jul 11.

Abstract

The study presented a Monte Carlo simulation of light transport in eight commonly used filtered facepiece respirators (FFRs) to assess the efficacy of UV at 254 nm for the inactivation of SARS-CoV-2. The results showed different fluence rates across the thickness of the eight different FFRs, implying that some FFR models may be more treatable than others, with the following order being (from most to least treatable): models 1512, 9105s, 1805, 9210, 1870+, 8210, 8110s and 1860, for single side illumination. The model predictions did not coincide well with some previously reported experimental data on virus inactivation when applied to FFR surfaces. The simulations predicted that FFRs should experience higher log reductions (>>6-log) than those observed experimentally (often limited to ~5-log). Possible explanations are virus shielding by aggregation or soiling, and a lack of the Monte Carlo simulations considering near-field scattering effects that can create small, localized regions of low UV photon probability on the surface of the fiber material. If the latter is the main cause in limiting practical UV viral decontamination, improvement might be achieved by exposing the FFR to UV isotropically from all directions, such as by varying the UV source to the FFR surface angle during treatment.

摘要

该研究通过蒙特卡罗模拟对 8 种常用过滤式面罩(FFR)中的光传输进行了研究,以评估 254nm 紫外线对 SARS-CoV-2 灭活的效果。结果表明,8 种不同 FFR 的厚度上存在不同的辐照率,这意味着某些 FFR 模型可能比其他模型更易于处理,以下是(从最容易处理到最不容易处理)的排序:单侧照明时,模型 1512、9105s、1805、9210、1870+、8210、8110s 和 1860。当将模型预测应用于 FFR 表面的病毒灭活实验数据时,与一些先前报道的实验数据并不吻合。模拟预测 FFR 应该经历比实验观察到的更高的对数减少(>>6-log)(通常限于~5-log)。可能的解释是病毒聚集或污染造成的屏蔽,以及缺乏考虑近场散射效应的蒙特卡罗模拟,这些效应会在纤维材料表面产生低紫外线光子概率的小局部区域。如果后者是限制实际紫外线病毒消毒的主要原因,可以通过从各个方向对 FFR 进行各向同性的紫外线照射来提高效率,例如在处理过程中改变紫外线源到 FFR 表面的角度。

相似文献

1
Modeling the efficiency of UV at 254 nm for disinfecting the different layers within N95 respirators.
J Biophotonics. 2021 Oct;14(10):e202100135. doi: 10.1002/jbio.202100135. Epub 2021 Jul 11.
2
Decontamination of SARS-CoV-2 contaminated N95 filtering facepiece respirators using artificial sun lamps.
J Appl Microbiol. 2021 Nov;131(5):2567-2578. doi: 10.1111/jam.15106. Epub 2021 May 6.
3
Effects of UV-C Disinfection on N95 and KN95 Filtering Facepiece Respirator Reuse.
Appl Environ Microbiol. 2022 Oct 11;88(19):e0122122. doi: 10.1128/aem.01221-22. Epub 2022 Sep 21.
4
Decontamination of SARS-CoV-2 contaminated N95 filtering facepiece respirators (FFRs) with moist heat generated by a multicooker.
Lett Appl Microbiol. 2021 Apr;72(4):366-374. doi: 10.1111/lam.13443. Epub 2020 Dec 31.
6
Filtering Facepiece Respirator (N95 Respirator) Reprocessing: A Systematic Review.
JAMA. 2021 Apr 6;325(13):1296-1317. doi: 10.1001/jama.2021.2531.
8
Room Temperature Wait and Reuse for Bioburden Reduction of SARS-CoV-2 on N95 Filtering Facepiece Respirators.
Appl Biosaf. 2021 Jun 1;26(2):103-111. doi: 10.1089/apb.20.0055. Epub 2021 Jun 2.
10
Evaluation of at-home methods for N95 filtering facepiece respirator decontamination.
Sci Rep. 2021 Oct 5;11(1):19750. doi: 10.1038/s41598-021-99129-8.

本文引用的文献

2
Assessment of saliva interference with UV-based disinfection technologies.
J Photochem Photobiol B. 2021 Apr;217:112168. doi: 10.1016/j.jphotobiol.2021.112168. Epub 2021 Mar 4.
3
Predictive Modeling of Virus Inactivation by UV.
Environ Sci Technol. 2021 Mar 2;55(5):3322-3332. doi: 10.1021/acs.est.0c07814. Epub 2021 Feb 12.
4
Rapid and complete inactivation of SARS-CoV-2 by ultraviolet-C irradiation.
Sci Rep. 2020 Dec 30;10(1):22421. doi: 10.1038/s41598-020-79600-8.
6
The effect of ultraviolet C radiation against different N95 respirators inoculated with SARS-CoV-2.
Int J Infect Dis. 2020 Nov;100:224-229. doi: 10.1016/j.ijid.2020.08.077. Epub 2020 Sep 3.
7
Light propagation within N95 filtered face respirators: A simulation study for UVC decontamination.
J Biophotonics. 2020 Dec;13(12):e202000232. doi: 10.1002/jbio.202000232. Epub 2020 Sep 22.
8
Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays.
J Infect Dis. 2020 Oct 1;222(9):1462-1467. doi: 10.1093/infdis/jiaa507.
9
Harmless Effects of Sterilizing 222-nm far-UV Radiation on Mouse Skin and Eye Tissues.
Photochem Photobiol. 2020 Jul;96(4):949-950. doi: 10.1111/php.13294. Epub 2020 Jul 11.
10
Effectiveness of N95 Respirator Decontamination and Reuse against SARS-CoV-2 Virus.
Emerg Infect Dis. 2020 Sep;26(9):2253-5. doi: 10.3201/eid2609.201524. Epub 2020 Jun 3.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验