Research and Development Division, Sapporo Holdings Ltd., 10 Okatome, Yaizu, Shizuoka 425-0013, Japan.
Fundamental Laboratory, Pokka Sapporo Food & Beverage Ltd., 1189-4, Nippacho, Yokohama, Kanagawa 223-0057, Japan.
J Nat Prod. 2021 Jul 23;84(7):2048-2052. doi: 10.1021/acs.jnatprod.1c00271. Epub 2021 Jun 30.
Unloading stress enhances oxidative stress, which in turn induces disuse muscle atrophy. This study evaluated the suppressive effect of lemon peel extract containing eriocitrin on muscle atrophy. Both lemon peel extract and eriocitrin suppressed weight loss in the gastrocnemius muscle under denervation in C57BL/6 mice. The mRNA level of ubiquitin ligases and their transcription factor were downregulated by eriocitrin. Eriocitrin inhibited the increase in lipid peroxidation and the ratio of glutathione disulfide/glutathione. These data suggest that eriocitrin ameliorated disuse muscle atrophy by suppressing the expression of ubiquitin ligase genes by its antioxidative effect.
卸荷应激会增强氧化应激，进而导致废用性肌肉萎缩。本研究评估了含有圣草次苷的柠檬皮提取物对肌肉萎缩的抑制作用。柠檬皮提取物和圣草次苷均能抑制 C57BL/6 小鼠去神经支配下腓肠肌的体重减轻。圣草次苷还下调了泛素连接酶及其转录因子的 mRNA 水平。圣草次苷抑制了脂质过氧化和谷胱甘肽二硫化物/谷胱甘肽比值的增加。这些数据表明，圣草次苷通过其抗氧化作用抑制泛素连接酶基因的表达，从而改善废用性肌肉萎缩。
