Wang Xingpeng, Tang Xiaofu, Wang Yunhui, Zhao Shengyin, Xu Ning, Wang Haoyu, Kuang Mingjie, Han Shijie, Jiang Zhensong, Zhang Wen
Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Phytother Res. 2025 Feb;39(2):1107-1138. doi: 10.1002/ptr.8420. Epub 2025 Jan 2.
With the development of medicine and chemistry, an increasing number of plant-derived medicines have been shown to exert beneficial therapeutic on the treatment of various physical and psychological diseases. In particular, by using physical chemistry methods, we are able to examine the chemical components of plants and the effects of these substances on the human body. Muscle atrophy (MA) is characterized by decreased muscle mass and function, is caused by multiple factors and severely affects the quality of life of patients. The multifactorial and complex pathogenesis of MA hinders drug research and disease treatment. However, phytotherapy has achieved significant results in the treatment of MA. We searched PubMed and the Web of Science for articles related to plant-derived substances and muscle atrophy. After applying exclusion and inclusion criteria, 166 and 79 articles met the inclusion criteria, respectively. A total of 173 articles were included in the study after excluding duplicates. The important role of phytoactives such as curcumin, resveratrol, and ginsenosides in the treatment of MA (e.g., maintaining a positive nitrogen balance in muscles and exerting anti-inflammatory and antioxidant effects) has been extensively studied. Unfortunately, MA dose not have to a single cause, and each cause has its own unique mechanism of injury. This review focuses on the therapeutic mechanisms of active plant components in MA and provides insights into the personalized treatment of MA.
随着医学和化学的发展，越来越多的植物源药物已被证明在治疗各种身心疾病方面具有有益的治疗作用。特别是，通过使用物理化学方法，我们能够检测植物的化学成分以及这些物质对人体的影响。肌肉萎缩（MA）的特征是肌肉质量和功能下降，由多种因素引起，严重影响患者的生活质量。MA的多因素和复杂发病机制阻碍了药物研究和疾病治疗。然而，植物疗法在MA的治疗中取得了显著成果。我们在PubMed和科学网中搜索了与植物源物质和肌肉萎缩相关的文章。应用排除和纳入标准后，分别有166篇和79篇文章符合纳入标准。排除重复项后，共有173篇文章纳入本研究。姜黄素、白藜芦醇和人参皂苷等植物活性成分在MA治疗中的重要作用（如维持肌肉正氮平衡以及发挥抗炎和抗氧化作用）已得到广泛研究。不幸的是，MA并非由单一原因引起，且每种原因都有其独特的损伤机制。本综述重点关注活性植物成分在MA中的治疗机制，并为MA的个性化治疗提供见解。
