Department of Medicine, Imperial College London, SW7 2BU, UK.
College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Regen Med. 2021 Jul;16(7):669-682. doi: 10.2217/rme-2021-0024. Epub 2021 Jun 30.
Atherosclerosis is a chronic inflammatory condition resulting in the formation of fibrofatty plaques within the intimal layer of arterial walls. The identification of resident stem cells in the vascular wall has led to significant investigation into their contributions to health and disease, as well as their therapeutic potential. Of these, mesenchymal stem cells (MSCs) are the most widely studied in human clinical trials, which have demonstrated a modulatory role in vascular physiology and disease. This review highlights the most recent knowledge surrounding the cell biology of MSCs, including their origin, identification markers and differentiation potential. The limitations concerning the implementation of MSC therapy are considered and novel solutions to overcome these are proposed.
动脉粥样硬化是一种慢性炎症性疾病，导致动脉壁内膜层中纤维脂肪斑块的形成。血管壁中固有干细胞的鉴定促使人们对其在健康和疾病中的作用及其治疗潜力进行了大量研究。其中，间充质干细胞（MSCs）是在人类临床试验中研究最广泛的一种，这些研究表明其在血管生理学和疾病中具有调节作用。本综述强调了围绕 MSCs 细胞生物学的最新知识，包括其起源、鉴定标志物和分化潜能。还考虑了 MSC 治疗实施的局限性，并提出了克服这些局限性的新方法。
