Perelman School of Medicine, Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stud Health Technol Inform. 2021 Jun 28;280:9-13. doi: 10.3233/SHTI210424.
The etiology of the adolescent idiopathic scoliosis (AIS) remains unknown. Variations in the sagittal profile of the spine between the early stage scoliotic and non-scoliotic pediatric patients have been shown. However, no quantitative study has shown the link between the sagittal profile and 3D deformity of the spine. 126 right thoracic scoliosis with spinal and 3D reconstructions were included. A 2D finite element model was developed for each of the sagittal curve types without any deformity in the frontal or axial planes. Physiological loadings were determined from the literature and were applied in the finite element model. The 3D deformation patterns of the models were compared to the 3D spinal patterns of the AIS with the same sagittal type. A significant correlation was found between the 3D deformity of the scoliotic curves and the numerical finite element simulation of the corresponding sagittal profile as determined by pattern correlation, p<0.001. The sagittal curve deformation patterns corresponded to the spinal deformities in the patients with the same sagittal curvature. Finite element models of the spines, representing different sagittal types in 126 AIS patients showed that deformation pattern of the sagittal types changes as a function of the spine curvature and associates with the patterns of 3D spinal deformity in AIS patients with the same sagittal curves. This finding provided evidence that the sagittal curve of the spine can determine the deformity patterns in AIS.
青少年特发性脊柱侧凸（AIS）的病因仍不清楚。已经显示出早期脊柱侧凸和非脊柱侧凸儿科患者脊柱矢状轮廓的变化。然而，没有定量研究表明矢状轮廓与脊柱 3D 畸形之间的联系。共纳入 126 例右侧胸弯伴脊柱和 3D 重建。为每个矢状曲线类型开发了一个没有正面或轴向平面变形的 2D 有限元模型。生理负荷从文献中确定，并应用于有限元模型中。将模型的 3D 变形模式与具有相同矢状类型的 AIS 的 3D 脊柱模式进行比较。通过模式相关性，发现脊柱侧凸曲线的 3D 变形与相应矢状曲线的数值有限元模拟之间存在显著相关性，p<0.001。矢状曲线变形模式与具有相同矢状曲率的患者的脊柱变形相对应。代表 126 例 AIS 患者不同矢状类型的脊柱有限元模型表明，矢状类型的变形模式随脊柱曲率而变化，并与具有相同矢状曲线的 AIS 患者的脊柱 3D 变形模式相关。这一发现提供了证据表明脊柱的矢状曲线可以确定 AIS 中的变形模式。
