Department of Orthopedic Surgery and Sports Medical Center and Sports Medical Research Institute, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.
GC Wellbeing Corporation, Seoul, Republic of Korea.
Medicine (Baltimore). 2021 Jul 2;100(26):e26542. doi: 10.1097/MD.0000000000026542.
GreenCross Wellbeing Corporation (GCWB) 106 is a food item based on Chrysanthemum zawadskii var. latilobum extract. It has an inhibitory effect on joint inflammation.
This study investigated the efficacy and safety of GCWB106 for osteoarthritis (OA) of the knee joint.
Overall, 121 participants with mild OA were recruited and randomly divided into two groups. One group received GCWB106 for 12 weeks and the other group received placebo for 12 weeks. Outcomes were evaluated using the Korean-Western Ontario and McMaster Universities Index (K-WOMAC), visual analog scale, Korean Short Form Health Survey 36 score, and laboratory test results.
After 12 weeks of study treatment, the GCWB106 group exhibited a significant improvement compared with the placebo group in overall K-WOMAC score (P = .042) and K-WOMAC physical function score (P = .015). The GCWB106 group showed significant improvement in the visual analog scale pain score (P < .001) compared with the placebo group after 6 weeks and 12 weeks; no adverse drug reactions or serious adverse events were reported in either group.
GCWB106 can safely reduce pain and improve knee function with therapeutic effects in OA of the knee joint.
Randomized, double-blind, placebo-controlled clinical study, Level I.
绿十字健康公司（GCWB）106 是一种基于菊花的食品提取物。它对关节炎症有抑制作用。
本研究旨在探讨 GCWB106 治疗膝关节骨关节炎（OA）的疗效和安全性。
共招募了 121 名轻度 OA 患者，并随机分为两组。一组接受 GCWB106 治疗 12 周，另一组接受安慰剂治疗 12 周。使用韩国-西安大略和麦克马斯特大学指数（K-WOMAC）、视觉模拟评分、韩国简短健康调查 36 分和实验室检查结果评估疗效。
治疗 12 周后，与安慰剂组相比，GCWB106 组的整体 K-WOMAC 评分（P=0.042）和 K-WOMAC 躯体功能评分（P=0.015）均显著改善。GCWB106 组的视觉模拟评分疼痛评分在治疗 6 周和 12 周后均显著低于安慰剂组（P<0.001）；两组均未报告不良反应或严重不良事件。
GCWB106 可安全减轻疼痛，改善膝关节功能，对膝关节 OA 具有治疗作用。
随机、双盲、安慰剂对照的临床研究，Ⅰ级。
