肝硬化中纤连蛋白的减少与脾脏大小有关。
Fibronectin decrease in liver cirrhosis is related to spleen size.
作者信息
de Angelis V, Zambon M, Toffolo L, Donada C, Molaro G L, Zuin R
机构信息
Centro Immuno-Transfusionale, Ospedale di Pordenone, Pordenone, Italia.
出版信息
Klin Wochenschr. 1988 Jun 15;66(12):524-6. doi: 10.1007/BF01736520.
We found a significantly lower plasma fibronectin concentration in cirrhotic patients than in controls, a significant inverse relationship between fibronectin and spleen size, but no correlation between fibronectin and hepatic blood flow, prothrombin time, or serum albumin. We suggest that the increased degradation in the enlarged spleen is more relevant than the decreased synthesis in reducing plasma fibronectin levels during liver cirrhosis with portal hypertension.
我们发现，肝硬化患者的血浆纤连蛋白浓度显著低于对照组，纤连蛋白与脾脏大小之间存在显著的负相关关系，但纤连蛋白与肝血流量、凝血酶原时间或血清白蛋白之间无相关性。我们认为，在伴有门静脉高压的肝硬化过程中，脾脏肿大导致的降解增加比合成减少在降低血浆纤连蛋白水平方面更为重要。
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