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[猪模型中COVID-19患者护理的机械通气测试方案]

[Mechanical ventilator test protocol for care of patients with COVID-19 in porcine model].

作者信息

García-Castro Giovanni, Latorre-Galeano David, Giraldo-Montoya Ángela María, Cabrales-Vega Rodolfo Adrián, Isaza-Velásquez Enrique, Gómez-González José Fernando, González-Corrales Juan Carlos, Ardila-Otero Álvaro, Flórez-Castañeda Indhira Tatiana, Chica-Builes Juan Fernando, Martínez-Ávila Ángela María, González-Colonia Luz Victoria

机构信息

Universidad Tecnológica de Pereira, Pereira, Colombia.

Fundación Universitaria del Área Andina, Pereira, Colombia.

出版信息

Rev Peru Med Exp Salud Publica. 2021 Jan-Mar;38(1):159-165. doi: 10.17843/rpmesp.2021.381.6505. Epub 2021 Jun 25.

DOI:10.17843/rpmesp.2021.381.6505
PMID:34190909
Abstract

As a result of the SARS-CoV-2 pandemic, health systems globally have seen a dramatic increase in the occupancy of intensive care units, with mechanical ventilators being a resource in high demand in the care of these patients. This article proposes a protocol for testing low-cost mechanical ventilators in pig models, as part of the development of locally manufactured biomedical equipment that can support the health crisis caused by the pandemic. The protocol addresses aspects that include the pre-test phase, anesthetic and airway management, laboratory monitoring, recovery and monitoring of the animal. This document presents to the academic community a validation protocol of a mechanical ventilator prototype in a pig specimen that can be a reference for its application and revalidation by other groups interested in the development of local and low-cost technologies.

摘要

由于新冠疫情,全球医疗系统的重症监护病房使用率急剧上升,机械通气设备成为护理这些患者的急需资源。本文提出了一项在猪模型中测试低成本机械通气设备的方案,作为本地制造生物医学设备开发的一部分,以应对疫情引发的健康危机。该方案涉及测试前阶段、麻醉和气道管理、实验室监测、动物恢复和监测等方面。本文向学术界展示了猪样本中机械通气设备原型的验证方案,可为其他对本地低成本技术开发感兴趣的团队在应用和重新验证时提供参考。

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[Mechanical ventilator test protocol for care of patients with COVID-19 in porcine model].[猪模型中COVID-19患者护理的机械通气测试方案]
Rev Peru Med Exp Salud Publica. 2021 Jan-Mar;38(1):159-165. doi: 10.17843/rpmesp.2021.381.6505. Epub 2021 Jun 25.
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Review of Anesthesia Versus Intensive Care Unit Ventilators and Ventilatory Strategies: COVID-19 Patient Management Implications.麻醉与重症监护病房呼吸机和通气策略的比较回顾:对 COVID-19 患者管理的影响。
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Concerns for low-resource countries, with under-prepared intensive care units, facing the COVID-19 pandemic.对于资源匮乏国家而言,其重症监护病房准备不足,正面临着新冠疫情,令人担忧。
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Ventilator management in the age of COVID-19: response to "Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients".新冠疫情时代的呼吸机管理:对“新冠患者专用重症监护病房的后勤与组织方面”的回应
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Surge capacity of intensive care units in case of acute increase in demand caused by COVID-19 in Australia.澳大利亚因 COVID-19 导致对重症监护病房的需求急性增加时的重症监护病房容量。
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About the mechanical ventilator as a shared resource for the Covid-19 pandemic.关于将机械通气设备作为应对新冠疫情的共享资源。
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"Water, water, everywhere": a challenge to ventilators in the COVID-19 pandemic.“水,水,无处不在”:新冠疫情中呼吸机面临的一项挑战。
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Cascaded robust control of mechanical ventilator using fractional order sliding mode control.使用分数阶滑模控制的机械通风机级联鲁棒控制。
Math Biosci Eng. 2022 Jan;19(2):1332-1354. doi: 10.3934/mbe.2022061. Epub 2021 Dec 3.

引用本文的文献

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Induction of subject-ventilator asynchrony by variation of respiratory parameters in a lung injury model in pigs.在猪肺损伤模型中通过改变呼吸参数来诱发人机不同步。
Respir Res. 2024 Oct 3;25(1):358. doi: 10.1186/s12931-024-02984-y.
2
Assessment of hemodynamics, blood gases, and lung histopathology of healthy Pig model on two different mechanical ventilators.在两种不同的机械通气机上对健康猪模型的血流动力学、血气和肺组织病理学进行评估。
Heliyon. 2022 Sep 22;8(9):e10736. doi: 10.1016/j.heliyon.2022.e10736. eCollection 2022 Sep.