Gaetini A, De Simone M, Urgesi A, Levis A, Resegotti A, Ragona R, Anglesio S
Third Department of Surgery, University of Turin, Italy.
J Surg Oncol. 1988 Sep;39(1):22-8. doi: 10.1002/jso.2930390105.
An original surgical method for gonadal protection in young women given pelvic radiation for Hodgkin's disease is presented. Lateral high ovarian transposition (LHAO) consists of the transposition of the ovaries into the paracolic gutter during staging laparotomy, after disconnecting the gonads from the fallopian tubes by dividing the tubo-ovarian vessels. The technique's effectiveness was assessed by a study using clinical investigation, radioimmunoassay (RIA) determination of sex hormones, and dosimetry; of 18 patients treated, 10 participated in the study. All but one have normal menses and hormone values, and one pregnancy occurred. We also calculated the doses absorbed by the ovaries and proved that, during inverted Y irradiation following LHAO, the ovaries are exposed to nearly one-half the dose they receive after traditional medial transposition. During subtotal nodal irradiation after LHAO, the irradiation dose is higher than after medialisation, but absolute values are minimal and castration is not induced.
本文介绍了一种为患有霍奇金病而接受盆腔放疗的年轻女性保护性腺的原创手术方法。侧高位卵巢移位术（LHAO）包括在分期剖腹手术期间，通过切断输卵管卵巢血管将性腺与输卵管分离后，将卵巢移位至结肠旁沟。通过一项使用临床研究、放射免疫测定法（RIA）测定性激素和剂量测定的研究来评估该技术的有效性；在接受治疗的18名患者中，10名参与了该研究。除一人外，所有人的月经和激素值均正常，且有一例妊娠。我们还计算了卵巢吸收的剂量，并证明在LHAO后的倒Y形照射期间，卵巢所接受的剂量几乎是传统内侧移位后所接受剂量的一半。在LHAO后的次全淋巴结照射期间，照射剂量高于内侧移位后，但绝对值极小且不会导致去势。
