少突胶质细胞的微环境相互作用。
Microenvironmental interactions of oligodendroglial cells.
机构信息
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USA.
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USA.
出版信息
Dev Cell. 2021 Jul 12;56(13):1821-1832. doi: 10.1016/j.devcel.2021.06.006. Epub 2021 Jun 29.
Abstract
Developmental myelination is a protracted process that extends well into postnatal life. Cell-intrinsic mechanisms operate in myelin-forming oligodendrocytes, as well as microenvironmental interactions that guide and modulate every aspect of myelination, from oligodendrocyte precursor cell migration to oligodendrocyte differentiation and the formation of stable myelin internodes. During development and throughout adult life, neuron-oligodendroglial interactions shape activity and experience-dependent myelin adaptations to fine-tune neural circuit dynamics and promote healthy neurological function.
摘要
发育性髓鞘形成是一个漫长的过程，一直持续到出生后。髓鞘形成少突胶质细胞中的细胞内在机制以及指导和调节髓鞘形成各个方面的微环境相互作用，从少突胶质前体细胞的迁移到少突胶质细胞的分化以及稳定的髓鞘节段的形成。在发育过程中和整个成年期，神经元-少突胶质细胞相互作用塑造了活动和经验依赖性髓鞘适应，以微调神经回路动力学并促进健康的神经功能。
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