Kwon Wookbong, Williamson Michael R, Deneen Benjamin
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Trends Neurosci. 2025 Jul 21. doi: 10.1016/j.tins.2025.06.009.
Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes suggest that such diversity may be derived from specialized populations. We provide an overview of the current state of research on astrocyte diversity and outline current challenges and knowledge gaps while also examining the developmental origins of these populations and how their interactions with neurons contribute to their functional heterogeneity. We highlight recent studies that provide evidence for functionally diverse astrocyte populations under homeostatic conditions and as an adaptive response to a range of experiences. This review provides a framework for understanding the dynamic and heterogeneous features of astrocytes across the CNS.
星形胶质细胞是中枢神经系统（CNS）中的神经胶质细胞，它们执行一系列对大脑活动至关重要的多样功能。对星形胶质细胞功能多样性的研究表明，这种多样性可能源自特定的细胞群体。我们概述了当前关于星形胶质细胞多样性的研究现状，概述了当前的挑战和知识空白，同时研究了这些细胞群体的发育起源，以及它们与神经元的相互作用如何导致其功能异质性。我们重点介绍了最近的研究，这些研究为稳态条件下以及作为对一系列经历的适应性反应的功能多样的星形胶质细胞群体提供了证据。这篇综述提供了一个理解中枢神经系统中星形胶质细胞动态和异质性特征的框架。
