Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Clin Chim Acta. 2021 Oct;521:107-115. doi: 10.1016/j.cca.2021.06.029. Epub 2021 Jun 28.
It is well established that overweight/obesity is closely associated with multiple health problems. Among these, dyslipidemia is the most important and main driving force behind pathologic development of cardio-metabolic disorders such as diabetes mellitus, atherosclerotic-related cardiovascular disease and hypertension. Notably, a subtype of dyslipidemia, metabolic related dyslipidemia, is now recognized as a vital link between obesity and multiple different cardiovascular diseases. This condition is characterized by increased low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) and very low density lipoprotein cholesterol (VLDL-C) as well as decreased high density lipoprotein cholesterol (HDL-C) in serum. In this review, we summarize the current understanding of metabolic related dyslipidemia and the potential mechanisms which lead to the pathogenesis of obesity/overweight. We focus on several novel lipid biomarkers such as pro-protein convertase subtilisin/kexin type 9 (PCSK9) and sphingosine-1-phosphate (S1P) and their potential use as biomarkers of metabolic related dyslipidemia.
超重/肥胖与多种健康问题密切相关，这一点已得到充分证实。在这些问题中，血脂异常是糖尿病、动脉粥样硬化性心血管疾病和高血压等代谢性心血管疾病病理发展的最重要和主要驱动因素。值得注意的是，血脂异常的一种亚型，即代谢相关性血脂异常，现在被认为是肥胖症与多种不同心血管疾病之间的重要联系。这种情况的特征是血清中低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）以及极低密度脂蛋白胆固醇（VLDL-C）增加，而高密度脂蛋白胆固醇（HDL-C）减少。在这篇综述中，我们总结了代谢相关性血脂异常的当前认识，以及导致肥胖/超重发病机制的潜在机制。我们重点介绍了几种新型脂质生物标志物，如前蛋白转化酶枯草溶菌素/柯萨奇蛋白酶 9（PCSK9）和鞘氨醇-1-磷酸（S1P），及其作为代谢相关性血脂异常生物标志物的潜在用途。
