He Qi, Li Zhenyu
College of Laboratory Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
Department of Pathophysiology, Basic Medical College, Chongqing Medical University, Chongqing, People's Republic of China.
Cancer Cell Int. 2021 Jun 30;21(1):326. doi: 10.1186/s12935-021-02030-7.
CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment.
钙/钙调蛋白依赖性蛋白激酶2（CaMK2）是一种参与多种细胞过程的多功能丝氨酸/苏氨酸蛋白激酶，对钙信号级联的转导至关重要。最近，研究突出了CaMK2在癌症发展中的作用。然而，CaMK2对癌症的具体影响尚未完全阐明。在本综述中，我们不仅总结了生物信息学分析所证实的CaMK2在一系列癌症中的表达变化，还总结了CaMK2在调节癌症进展（如增殖和转移）中的重要作用。此外，我们描述了CaMK2对癌症干性和耐药性的功能影响。了解CaMK2在癌症中的关键作用和机制将有助于开发一种有前景的癌症治疗策略。
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