银屑病的口服锌负荷试验。

An oral zinc loading test in psoriasis.

作者信息

Linder N, Statter M, Leibovici V, Livshin R, Schindler A, Tamir I

机构信息

Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.

出版信息

Metabolism. 1988 Sep;37(9):807-9. doi: 10.1016/0026-0495(88)90111-4.

DOI:10.1016/0026-0495(88)90111-4

PMID:3419320

Abstract

Changes of zinc in body fluids were evaluated in 12 patients with extensive psoriasis and compared with those of 11 healthy volunteers, using an oral zinc loading test. Plasma zinc levels and urinary zinc excretion were measured by atomic absorption spectrophotometry. No significant difference was found between plasma zinc levels and urinary zinc excretion following an overnight fast. Both groups showed extensive increases in urinary zinc excretion following the loading test. The peak levels of plasma zinc were significantly lower in the psoriatic patients two and four hours after zinc ingestion (P less than .01 and P less than .02, respectively).

摘要

采用口服锌负荷试验，对12例广泛性银屑病患者体液中锌的变化进行评估，并与11名健康志愿者进行比较。用原子吸收分光光度法测定血浆锌水平和尿锌排泄量。空腹过夜后，血浆锌水平和尿锌排泄量未发现显著差异。两组在负荷试验后尿锌排泄量均大幅增加。银屑病患者在摄入锌后两小时和四小时血浆锌峰值水平显著较低（分别为P<0.01和P<0.02）。