Babcock A K, Henkin R I, Aamodt R L, Foster D M, Berman M
Metabolism. 1982 Apr;31(4):336-47. doi: 10.1016/0026-0495(82)90108-1.
The effects of oral zinc loading on zinc metabolism were studied in 10 patients with taste and smell dysfunction following oral administration of Zn-65 (physical t1/2 = 245 d) and subsequent administration of oral stable zinc. Patients took an ad libitum dietary zinc intake of 8-13 mg daily for 290-440 days (mean, 336) following Zn-65 administration, followed by an intake of an additional 100 mg/day of zinc ion (as ZnSO4) over the next 112-440 days (mean, 307). A previously developed compartmental model, based on five day studies of patients with taste and smell dysfunction, was extended in such a way that it was consistent with both short term and long term kinetics. In this extended model, the turnover of 90% of total body zinc, previously unaccounted for by the kinetics in the short term studies could be explained by a single compartment, as postulated in the short term studies. Using the model, it was found that changes in the rate constants for gastrointestinal absorption and renal excretion of zinc were both necessary and sufficient to explain the changes seen in the kinetic curves following oral zinc loading. Michaelis-Menten type saturation mechanisms were adequate to explain the observed parameter changes. These changes also accounted for the observed mean plasma zinc mass increase of only 37% above pre-load levels in face of an 11-fold increase in zinc intake.
在10例味觉和嗅觉功能障碍病人中，口服锌 - 65（物理半衰期 = 245天）后再给予口服稳定锌，研究口服锌负荷对锌代谢的影响。病人在服用锌 - 65后自愿摄入每日8 - 13毫克的膳食锌，持续290 - 440天（平均336天），随后在接下来的112 - 440天（平均307天）中额外摄入100毫克/天的锌离子（以硫酸锌形式）。基于对味觉和嗅觉功能障碍病人进行的为期五天的研究，之前建立的房室模型得以扩展，使其与短期和长期动力学均保持一致。在这个扩展模型中，如短期研究所假设的那样，全身90%的锌周转率（此前短期研究的动力学未能解释）可由一个单一房室来解释。利用该模型发现，锌的胃肠道吸收和肾脏排泄速率常数的变化对于解释口服锌负荷后动力学曲线中所观察到的变化而言，既是必要的也是充分的。米氏类型的饱和机制足以解释所观察到的参数变化。面对锌摄入量增加了11倍的情况，这些变化也解释了所观察到的血浆锌质量平均仅比负荷前水平增加37%的现象。
