降钙素原和预后营养指数预测重症监护病房脓毒症患者的死亡率：一项初步研究。
Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study.
机构信息
Department of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College Hospital, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.
Department of Anesthesiology, Osaka Medical College, Osaka Medical College Hospital, Takatsuki, Osaka, 569-8686, Japan.
出版信息
BMC Res Notes. 2021 Jun 30;14(1):245. doi: 10.1186/s13104-021-05659-9.
OBJECTIVE
Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis.
RESULTS
Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsis patients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001-1.0013 (p = 0.0320).
目的
脓毒症是危重症患者死亡的主要原因。本研究旨在确定降钙素原（PCT）值是否可以预测脓毒症患者的死亡率。
结果
受试者工作特征（ROC）曲线分析、Log-rank 检验和多因素分析确定 PCT 值和预后营养指数（PNI）是脓毒症患者死亡的预测因素。第 1 天的 PCT 值是早期死亡率的预测指标，即 ICU 入院后 7 天内死亡；ROC 曲线分析显示 AUC 为 0.84，灵敏度为 89%，特异性为 77%；多因素分析显示 OR 为 1.0007，95%CI 为 1.0001-1.0013（p=0.0320）。
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