Quinto I, De Marinis E, De Dominicis G, Della Morte R, Staiano N
Institute of Cellular and Molecular Biochemistry, 2nd Medical School, University of Naples, Italy.
Mutat Res. 1988 Sep;201(1):113-6. doi: 10.1016/0027-5107(88)90117-0.
The antitumor drugs ifosfamide (IF) and trofosfamide (TF) were evaluated for their capability to induce sperm abnormalities in (C3H X C57BL/6)F1 mice. A statistically significant increase in teratospermia was observed at the 35th day after 5 daily consecutive intraperitoneal injections of the drugs at doses of 25, 50, 100 mg/kg b.w. of TF and 100 mg/kg b.w. of IF. Thus, IF and TF are able to interfere with the differentiation process of spermatogenic cells.
对抗肿瘤药物异环磷酰胺（IF）和曲磷酰胺（TF）诱导（C3H×C57BL/6）F1小鼠精子异常的能力进行了评估。连续5天每天腹腔注射剂量为25、50、100mg/kg体重的TF和100mg/kg体重的IF后，在第35天观察到精子畸形率有统计学意义的增加。因此，IF和TF能够干扰生精细胞的分化过程。
