Quinto I, De Marinis E, Mallardo M, Arcucci A, Della Morte R, Staiano N
Dipartimento di Biochemica e Biotecnologie Mediche, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Mutat Res. 1989 Dec;224(4):405-8. doi: 10.1016/0165-1218(89)90064-5.
DNOC, Ferbam and Imidan were tested in (C3H X C57BL/6) F1 mice to assess their potential testicular toxicity. Chemicals were administered i.p. and per os at different doses for 5 consecutive days. After 35 days the testicular was toxicity was evaluated by measuring the testicular weights, the sperm counts and the percentage of abnormal sperm. DNOC and Imidan failed to induce teratospermia in mice treated by both routes of administration. Conversely Ferbam induced a statistically significant increase in teratospermia only following per os administration to mice at a dose of 1000 mg/kg b.w./day. These data indicate that per os administration of Ferbam succeeded in producing active metabolites able to interfere with the differentiation process of spermatogenic cells.
对二硝甲酚（DNOC）、福美铁和益棉磷在（C3H×C57BL/6）F1小鼠中进行了测试，以评估它们潜在的睾丸毒性。通过腹腔注射和口服不同剂量的化学物质，连续给药5天。35天后，通过测量睾丸重量、精子计数和异常精子百分比来评估睾丸毒性。通过两种给药途径处理的小鼠中，DNOC和益棉磷均未诱导精子畸形。相反，仅在以1000mg/kg体重/天的剂量口服给药小鼠后，福美铁诱导精子畸形出现统计学上的显著增加。这些数据表明，口服福美铁成功产生了能够干扰生精细胞分化过程的活性代谢物。
