Department of Dermatology, Xiangya Hospital, Central South University, Xiangya Road, Kaifu District, Changsha, Hunan, 410008, People's Republic of China.
Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Xiangya Road, Kaifu District, Changsha, Hunan, 410008, People's Republic of China.
Arch Dermatol Res. 2022 Sep;314(7):643-650. doi: 10.1007/s00403-021-02259-2. Epub 2021 Jul 1.
Rosacea is a common chronic facial inflammatory skin disease. However, treatment for "difficult-to-treat rosacea" cases has not been established. This 48-week, prospective, observational study analyzed patients who underwent three non-insulated fractional microneedle radiofrequency (NFMRF) sessions at 2-month intervals. Therapy efficacy, epidermal barrier function, and side effects were evaluated. 34 subjects completed the trial. NFMRF resulted in CEA score reduction from 2.65 ± 0.59 to 1.56 ± 0.50 (P < 0.001) and mean DLQI reduction from 16.70 ± 3.55 to 10.48 ± 2.92 (P < 0.001). The successes of CEA (44.12 vs. 2.94%), IGA (91.67 vs. 25.00%), and flushing (58.82 vs. 26.47%) were observed. Among 34 patients, 22 reported "excellent" or "good" improvement and 30 were "very" or "relatively" satisfied. Skin barrier results revealed that hemoglobin content significantly decreased from 376.47 ± 71.29 at visit 0 to 161.32 ± 52.86 at visit 3. 2 of 30 patients followed-up at 6 months had a relapse at 18 and 20 weeks, respectively. No serious side effects were observed. NFMRF alone results in visible improvement and has great efficacy for difficult-to-treat rosacea without compromising patient safety or damaging the skin barrier.
酒渣鼻是一种常见的慢性面部炎症性皮肤疾病。然而，对于“难治性酒渣鼻”病例的治疗尚未确立。本 48 周前瞻性观察研究分析了接受 3 次非绝缘性分段微针射频（NFMRF）治疗、每 2 个月 1 次的患者。评估了治疗效果、表皮屏障功能和不良反应。34 例患者完成了试验。NFMRF 导致 CEA 评分从 2.65±0.59 降至 1.56±0.50（P<0.001），平均 DLQI 评分从 16.70±3.55 降至 10.48±2.92（P<0.001）。CEA（44.12%比 2.94%）、IGA（91.67%比 25.00%）和潮红（58.82%比 26.47%）成功率有所提高。在 34 例患者中，22 例报告“非常好”或“好”的改善，30 例报告“非常”或“相对”满意。皮肤屏障结果显示，血红蛋白含量从 0 时的 376.47±71.29 显著降低至 3 时的 161.32±52.86。30 例在 6 个月随访的患者中有 2 例分别在 18 周和 20 周时复发。未观察到严重不良反应。NFMRF 单独使用可显著改善难治性酒渣鼻，且疗效显著，不会损害患者安全或皮肤屏障。
