Yantai Institute of Coastal Zone Research, Center for Ocean Mega-Science, Chinese Academy of Sciences, Yantai 264003, People's Republic of China.
Yantai Institute of Coastal Zone Research, Center for Ocean Mega-Science, Chinese Academy of Sciences, Yantai 264003, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Fitoterapia. 2021 Sep;153:104983. doi: 10.1016/j.fitote.2021.104983. Epub 2021 Jun 28.
Six new sesquiterpenoids including three bisabolane derivatives, trichobisabolins O, O, and P (1-3), two nerolidol derivatives, trichonerolins A and B (4 and 5), one acorane, trichoacorin A (6), along with one new steroid, isoergokonin B (7), were isolated from the culture of Trichoderma brevicompactum A-DL-9-2 obtained from the inner tissue of the red alga Chondria tenuissima. Their structures and relative configurations were assigned by interpretation of 1D/2D NMR and MS data. As acyclic sesquiterpenoids, compounds 4 and 5 were discovered from Trichoderma for the first time. Compounds 1-7 were evaluated for the inhibition of some marine-derived organisms, in which, 3 and 4/5 exhibited potent inhibition against Amphidinium carterae and Chattonella marina with IC of 1.8 μg/mL and 1.2 μg/mL, respectively. In addition, compound 7 could inhibit the growth of Pseudoalteromonas citrea with an MIC value of 64 μg/mL.
从采自红色海藻 Chondria tenuissima 内部组织的短密青霉 A-DL-9-2 的发酵液中分离得到了 6 种新的倍半萜类化合物，包括 3 种倍半萜衍生的双醇类化合物，即三葫芦巴醇 O、O 和 P（1-3），2 种橙花叔醇衍生物，即三橙醇 A 和 B（4 和 5），1 种阿罗烷类化合物，即三阿罗醇 A（6），以及 1 种新甾体化合物，即异麦角甾酮 B（7）。通过 1D/2D NMR 和 MS 数据分析，确定了这些化合物的结构和相对构型。作为无环倍半萜类化合物，化合物 4 和 5 是首次从青霉属中发现的。对化合物 1-7 进行了一些海洋来源生物抑制活性的评价，其中化合物 3 和 4/5 对 Amphidinium carterae 和 Chattonella marina 的抑制活性较强，IC 分别为 1.8 μg/mL 和 1.2 μg/mL。此外，化合物 7 对 Pseudoalteromonas citrea 的生长具有抑制作用，MIC 值为 64 μg/mL。
